Evidence map›Paper›PMID 41899867›Full record

ArticleBioengineering (Basel, Switzerland)2026

Establishment of a 3D Multicellular HCC Tumor Spheroid Model to Unravel Nrf2's Influence on the Tumor Immune Microenvironment.

Nicole Böttcher, Philipp Krumm, Rosanna Huchzermeier, Lara Berschkeit, Johanna Vollmer, Julie Dick, Thomas Pufe, Athanassios Fragoulis

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole BöttcherDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.ORCID 0009-0002-9030-9329
Philipp KrummDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.ORCID 0009-0001-5177-4917
Rosanna HuchzermeierDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.
Lara BerschkeitDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.
Johanna VollmerDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.ORCID 0009-0009-9715-0788
Julie DickDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.
Thomas PufeDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-7886-9211
Athanassios FragoulisDepartment of Anatomy and Cell Biology, Uniklinik RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-6973-3080

Funding

Universitätsklinikum Aachen IA692101
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death, yet adequate

Indexed as

3D cell cultureHCCmulticellular tumor spheroidN-HCC25Nrf2spheroidtumor associated macrophagestumor immune microenvironment

Identifiers

PMID41899867
PMCPMC13023928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.