An Enhanced Electrochemiluminescence Immunoassay Platform via Optimized Magnetic Bead Uniformity for Reliable Thyroid-Stimulating Hormone Monitoring.

Hengbo Lei, Xinyu Huang, Xiang Cao, Yuguo Tang, Yang Ge

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hengbo LeiSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.

Xinyu HuangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.

Xiang CaoSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.

Yuguo TangSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0001-9668-6841

Yang GeShenyang Guoke Bright Medical Technology Co., Ltd., Shenyang 110170, China.ORCID 0000-0001-8080-601X

Funding

Shenzhen Municipal Science and Technology Research and Development Fund KJZD20240903101100001the Natural Science Foundation of Liaoning Province (General Program) 2024-MS-274

6 · The paper itself

Abstract

Electrochemiluminescence immunoassay (ECLIA) is widely used in clinical diagnostics owing to its high sensitivity, broad dynamic range, and excellent analytical stability. However, the influence of magnetic bead deposition behavior on electrochemiluminescence (ECL) signal performance remains insufficiently characterized. In this study, a quantitative evaluation method for magnetic bead distribution uniformity on the electrode surface was established and applied to optimize fluidic parameters in an ECLIA measurement system. By combining microscopic imaging with image analysis, magnetic bead spreading behavior under different flow conditions was systematically characterized and correlated with luminescence signal intensity. Optimization of the flow rate (18.46 µL·s

Indexed as

electrochemical luminescence systemimage processingmagnetic bead arrangementTSH detection

Identifiers

PMID41899864

DOI10.3390/bioengineering13030333

PMCPMC13024379

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.