Androgen Receptor Point Mutations: A Mechanism of Therapeutic Resistance and a Framework for Rational Drug Design.

Avan Colah, Sára Ferková, Han Zhang, Glenn Liu, Leonard MacGillivray, Pierre-Luc Boudreault, William Ricke

Abstract readReview

In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Avan ColahDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0009-0009-3813-8949

Sára FerkováDépartement de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID 0009-0002-2890-6528

Han ZhangDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-8032-857X

Glenn LiuDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.

Leonard MacGillivrayDépartement de Chime, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.

Pierre-Luc BoudreaultDépartement de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID 0000-0002-2032-7970

William RickeDepartment of Urology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-9807-2090

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

androgen receptor ligand-binding domainmolecular mechanismspoint mutationtherapeutic resistance

Identifiers

PMID41899643

DOI10.3390/cancers18061043

PMCPMC13025137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.