Evidence map›Paper›PMID 41899573›Full record

ReviewCancers2026

Conventionally Fractionated Radiotherapy (CFRT) Versus Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis of Comparative Studies.

Giampaolo Montesi, Marcin Miszczyk, Rita Marina Niespolo, Giorgia Capezzali, Francesco Cellini, Nunziata D'Abbiero, Michele Fiore, Domenico Genovesi, Mariangela La Macchia, Marco Lupattelli and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giampaolo MontesiRadiation Oncology Unit, Radiologic Sciences Department, AST Pesaro Urbino, 61121 Pesaro, Italy.ORCID 0000-0002-8603-9496
Marcin MiszczykDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-4375-0827
Rita Marina NiespoloRadiation Oncology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Giorgia CapezzaliRadiation Oncology Unit, Radiologic Sciences Department, AST Pesaro Urbino, 61121 Pesaro, Italy.
Francesco CelliniDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy.ORCID 0000-0002-2145-2300
Nunziata D'AbbieroRadiotherapy Unit, University Hospital of Parma, 43126 Parma, Italy.
Michele FioreResearch Unit of Radiation Oncology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.ORCID 0000-0003-1889-4578
Domenico GenovesiDepartment of Radiation Oncology, "S.S. Annunziata" Chieti Hospital, 66100 Chieti, Italy.
Mariangela La MacchiaRadiation Oncology Unit, Radiologic Sciences Department, AST Pesaro Urbino, 61121 Pesaro, Italy.
Marco LupattelliRadiation Oncology Section, Department of Medicine and Surgery, University of Perugia and Perugia General Hospital, 06129 Perugia, Italy.
Giovanna MantelloRadiotherapy Department, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.ORCID 0000-0001-9314-6006
Fabio MatroneDivision of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-2292-0444
Luca NicosiaAdvanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, 37024 Negrar di Valpolicella, Italy.ORCID 0000-0002-0731-8041
Nicola SimoniRadiotherapy Unit, University Hospital of Parma, 43126 Parma, Italy.
Pierfrancesco FrancoDepartment of Translational Medicine (DIMET), University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0003-2276-0687
Francesca De FeliceRadiation Oncology, Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0002-5119-8358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStereotactic body radiotherapy (SBRT) has gained increasing interest in the treatment of locally advanced pancreatic cancer (LAPC), although its effectiveness has not been defined in randomized trials. This systematic review and meta-analysis aimed to compare clinical outcomes and treatment-related toxicity between SBRT and CFRT in LAPC.

methodsThis analysis was performed in accordance with PRISMA guidelines (PROSPERO: CRD420251128943). MEDLINE and Scopus were searched for comparative studies published between January 2015 and July 2025. Five retrospective studies comprising 768 patients fulfilled the eligibility criteria. Pooled hazard ratios (HRs) were calculated for overall survival (OS) and progression-free survival (PFS), while risk ratios (RRs) were estimated for severe (grade ≥ 3) acute toxicity using random-effects models. Study quality was evaluated using the ROBINS-I tool.

resultsNo significant OS or PFS differences were observed between SBRT and CFRT. SBRT was associated with a lower incidence of severe acute toxicity. The overall risk of bias across studies was moderate.

conclusionsSBRT appears to achieve survival outcomes comparable to CFRT with a favorable acute toxicity profile in patients with LAPC. Nevertheless, the current evidence is limited by retrospective designs and heterogeneity, highlighting the need for prospective randomized trials to define the role of SBRT in this setting.

Indexed as

chemoradiotherapylocally advanced pancreatic cancermeta-analysispancreatic adenocarcinomastereotactic body radiotherapysystematic review

Identifiers

PMID41899573
PMCPMC13024495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.