Evidence map›Paper›PMID 41899493›Full record

ReviewCancers2026

Transplant Oncology in Evolution: Emerging Roles for Liver Transplant Beyond Hepatocellular Carcinoma.

Ahmed A Abdelhakeem, Conor D O'donnell, Dina Elantably, Oluwatayo Adeoye, Hani M Babiker, Jason Starr, Liu Yang, Jordan D Legout, Beau Toskich, Denise M Harnois and 3 more

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed A AbdelhakeemDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0001-7186-1332
Conor D O'donnellDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0009-0009-6291-846X
Dina ElantablyDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0002-4706-3864
Oluwatayo AdeoyeDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0009-0002-3007-5292
Hani M BabikerDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0002-9368-6296
Jason StarrDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0002-8674-8102
Liu YangDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.
Jordan D LegoutDepartment of Radiology, Division of Interventional Radiology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0003-3608-726X
Beau ToskichDepartment of Radiology, Division of Interventional Radiology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0003-4707-7921
Denise M HarnoisDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0001-7307-2900
Jeremy C JonesDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0001-7793-9540
Kristopher P CroomeDepartment of Transplant, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0001-7725-703X
Umair MajeedDepartment of Medicine, Division of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL 32224, USA.ORCID 0000-0002-4225-7555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver transplantation has emerged as a curative treatment option for selected patients with unresectable hepatic malignancies beyond hepatocellular carcinoma, marking a paradigm shift in transplant oncology. For colorectal cancer liver metastases (CRLM), prospective trials have demonstrated that highly selected patients achieve 5-year OS rates of 60-83%, with the Oslo score identifying optimal candidates for transplantation. Perihilar cholangiocarcinoma (pCCA) has been successfully treated using strict patient selection criteria combined with neoadjuvant therapy, achieving 5-year OS rates of 50-68%, though emerging data suggests chemotherapy-based approaches may be preferable to radiation in selected cases. Intrahepatic cholangiocarcinoma (iCCA), previously considered a contraindication to transplantation, can now achieve excellent long-term outcomes (79.5% 5-year OS) in patients demonstrating sustained response to neoadjuvant chemotherapy and radioembolization, with metabolic tumor volume < 70 cm

Indexed as

cholangiocarcinomacolorectal liver metastasesintrahepaticliver transplantationperihilar

Identifiers

PMID41899493
PMCPMC13025092

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.