Evidence map›Paper›PMID 41899464›Full record

ArticleCurrent issues in molecular biology2026

Dietary Fructose and Palmitic Acid Induce Shared and Divergent Transcriptional Responses in the Larval Midgut of

Laura Castañeda-Partida, Myriam Campos-Aguilar, Luis Felipe Santos-Cruz, Lizbeth Abigail Piña-Soto, Santiago Cristobal Sigrist Flores, María Eugenia Heres-Pulido, Irma Elena Dueñas-García, Elías Piedra-Ibarra, Rafael Jiménez-Flores, Alberto Ponciano-Gómez

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura Castañeda-PartidaToxicología Genética, Biología, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.ORCID 0000-0002-1737-7424
Myriam Campos-AguilarLaboratorio de Inmunología (UMF), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.ORCID 0000-0002-7112-7645
Luis Felipe Santos-CruzToxicología Genética, Biología, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.ORCID 0000-0001-8212-9606
Lizbeth Abigail Piña-SotoLaboratorio de Inmunología (UMF), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
Santiago Cristobal Sigrist FloresLaboratorio de Inmunología (UMF), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
María Eugenia Heres-PulidoToxicología Genética, Biología, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.ORCID 0000-0002-8731-877X
Irma Elena Dueñas-GarcíaToxicología Genética, Biología, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
Elías Piedra-IbarraFisiología Vegetal (Unidad de Biología Tecnología y Prototipos), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
Rafael Jiménez-FloresLaboratorio de Inmunología (UMF), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
Alberto Ponciano-GómezLaboratorio de Inmunología (UMF), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios N° 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.ORCID 0000-0002-1801-6575

Funding

DGAPA UNAM IN213425
6 · The paper itself

Abstract

backgroundHigh-energy diets enriched in simple sugars and saturated fatty acids alter metabolic homeostasis, yet how distinct nutrients are integrated at the transcriptional level remains incompletely understood.

methodsHere, we profiled the larval midgut transcriptome of

resultsThe results revealed extensive transcriptional remodeling, with most responses being diet-specific, alongside a conserved core of genes regulated across all treatments. Shared transcriptional signatures were associated with proteostasis and amino acid transport pathways. Comparative and pattern-based analyses further uncovered discordant gene sets and pathway enrichments that were unique to individual diets or to the combined exposure. Notably, the mixed diet induced distinct expression patterns with specific functional signatures that were not predictable from either nutrient alone.

conclusionsTogether, these findings indicate that the larval midgut integrates carbohydrate and lipid inputs through coordinated and context-dependent transcriptional responses, highlighting the importance of nutrient combinations in shaping epithelial metabolic programs.

Indexed as

dietary stressDrosophila melanogasterfructosemidgutnutrient integrationpalmitic acidtranscriptomics

Identifiers

PMID41899464
PMCPMC13025958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.