ReviewCurrent issues in molecular biology2026
New Frontiers in the Pathophysiology of Hypertensive Pregnancy Disorders: A Systematic Review of Molecular Insights into Preeclampsia.
Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundHypertensive disorders during pregnancy (HDP) pose a significant health risk to both mothers and infants. Despite extensive research, the precise pathophysiology of preeclampsia remains elusive, posing a formidable challenge to clinicians and researchers alike. This systematic review aims to summarize recent advances in understanding PE pathophysiology with particular emphasis on molecular mechanisms involved, as well as the roles and effects of genetics and hormones in PE.
methodsThe literature was searched to identify clinical research investigating the underlying molecular and cellular mechanisms of PE, along with the genetic, hormonal, and pathophysiological changes. All studies were solicited from the databases PubMed, Scopus, and ScienceDirect according to the PRISMA 2020 workflow. The eligibility criteria were developed using the PECO (Population, Exposure, Comparator, Outcome) framework.
resultsThe most common molecular mechanisms found were: angiogenetic dysregulation and endothelial injury mechanism (
conclusionThe complex development of hypertensive pregnancy disorders reflects numerous molecular mechanisms implicated in this process. From genetic and environmental influences on placental dysfunction to epigenetic changes and systemic dysregulation, each mechanism contributes to health outcomes for both the mother and the child.
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