Evidence map›Paper›PMID 41899427›Full record

ArticleCurrent issues in molecular biology2026

Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models.

Matvey M Tsyganov, Danna Zh Bulatova, Anastasia A Fedorenko, Dmitry M Loos, Pavel E Nikiforov, Irina A Tsydenova, Aigerim A Bayanbayeva, Zhansaya Sharipkhanova, Sofia S Timoshenko, Marina K Ibragimova

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Matvey M TsyganovCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.ORCID 0000-0001-7419-4512
Danna Zh BulatovaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.
Anastasia A FedorenkoCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.ORCID 0000-0003-3297-1680
Dmitry M LoosCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.
Pavel E NikiforovGoldberg Research Institute of Pharmacology and Regenerative Medicine, 3 Lenin Avenue, Tomsk 634028, Russia.
Irina A TsydenovaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.ORCID 0000-0002-2716-3075
Aigerim A BayanbayevaBiochemistry and Molecular Biology Division, Siberian State Medical University, 2 Moskovsky Trakt, Tomsk 634050, Russia.
Zhansaya SharipkhanovaBiochemistry and Molecular Biology Division, Siberian State Medical University, 2 Moskovsky Trakt, Tomsk 634050, Russia.
Sofia S TimoshenkoCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.
Marina K IbragimovaCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, St. Kooperativny 5, Tomsk 634009, Russia.

Funding

Russian Science Foundation 22-15-00169 (Continuation)
6 · The paper itself

Abstract

Understanding the molecular mechanisms of carcinogenesis, including disruptions in the homologous recombination system, is fundamental to understanding malignant transformation. Dysfunction of homologous recombination genes, such as MATERIALS AND

methodsMale outbred ICR (CD-1) laboratory mice (

resultsTumor formations were identified in laboratory animals two months after 3-methylcholanthrene. Histological analysis revealed morphological changes in a pleomorphic cell tumor, forming diverse, multidirectional fascicular and swirling structures, as well as large solid foci composed of markedly polymorphic spindle-shaped and epithelioid cells. Analysis of copy number aberrations in the examined samples showed that the frequency of

conclusionsOur findings confirm that MC and TCA influence tumor formation and reveal that suppression of homologous recombination genes may contribute to this process. In addition, it has been established that as tumors progress, the expression of DNA repair genes declines and aberrant gene states accumulate. These data emphasize the importance of studying the state of DNA repair genes for the development of more effective strategies for cancer diagnosis and therapy.

Indexed as

3-methylcholanthreneBrca1chemo-induced carcinogenesischemosensitivityexpressionhomologous recombination genestrichloroacetic acid

Identifiers

PMID41899427
PMCPMC13025133

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