Evidence map›Paper›PMID 41899396›Full record

ArticleCurrent issues in molecular biology2026

Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis.

Elmehdi Fraj, Amine Elbouzidi, Haytham Bouammali, Hanane Jaouani, Chaymae Bourhou, Mohamed Addi, Susu M Zughaier, Allal Challioui, Rachid Touzani, Boufelja Bouammali

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elmehdi FrajLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0009-0003-2692-5917
Amine ElbouzidiLaboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0000-0003-0314-8484
Haytham BouammaliLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0000-0003-4094-3807
Hanane JaouaniLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0009-0005-4747-5825
Chaymae BourhouLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0009-0004-2137-2599
Mohamed AddiLaboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0000-0002-3973-6694
Susu M ZughaierCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0001-7487-8770
Allal ChalliouiLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.
Rachid TouzaniLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0000-0001-7333-697X
Boufelja BouammaliLaboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.ORCID 0009-0008-3075-6040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of new anti-inflammatory agents with improved safety and efficacy remains a major therapeutic challenge, particularly in light of the adverse effects associated with conventional nonsteroidal anti-inflammatory drugs. In this study, a series of new flavone derivatives were synthesized and evaluated for their inhibitory activities against Cyclooxygenase-1 (COX-1), Cyclooxygenase-2 (COX-2), and 5-Lipooxygenase (5-LOX) through combined in vitro and in silico approaches. Biological screening demonstrated that several derivatives exhibited moderate to strong inhibitory activity across the three enzymes, with IC

Indexed as

5-LOX molecular dockingADMETanti-inflammatory activitiesCOX-2flavone–tetrazole hybrids

Identifiers

PMID41899396
PMCPMC13025331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.