Roles of DNA Damage Response Pathway in the Regulation of the Nuclear Envelope.

Yasunao Kamikawa, Zuqian Wu, Kenshiro Fujise, Kazunori Imaizumi, Atsushi Saito

Abstract readReview

In one paragraph

Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yasunao KamikawaDepartment of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Hiroshima, Japan.

Zuqian WuDepartment of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Hiroshima, Japan.

Kenshiro FujiseDepartment of Frontier Science and Interdisciplinary Research, Faculty of Medicine, Kanazawa University, 13-1 Takara-Machi, Kanazawa 920-8640, Ishikawa, Japan.ORCID 0000-0001-9018-6504

Kazunori ImaizumiThe Osaka Medical Research Foundation for Intractable Diseases, 3-7-11 Minamisumiyoshi, Sumiyoshi-ku, Osaka 558-0041, Osaka, Japan.

Atsushi SaitoDepartment of Frontier Science and Interdisciplinary Research, Faculty of Medicine, Kanazawa University, 13-1 Takara-Machi, Kanazawa 920-8640, Ishikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nuclear envelope (NE) functions as a barrier between the cytoplasm and nucleus. Over the past decade, NE has revealed unexpectedly divergent structural alterations. NE rupture triggers the uncontrollable exchange of macromolecules across the NE and potentially causes DNA damage. Conversely, a recent study demonstrated that DNA damage induces NE rupture and that one of the major kinases in the DNA damage response (DDR) pathway, ataxia telangiectasia and Rad3-related protein, ATR, is a key molecule in these events. Here, we review the role of the DDR pathway in NE regulation, with a focus mainly on ATR.

Indexed as

ATRcell cycleDNA damage responselaminnuclear envelopenuclear envelope rupturenuclear lamina

Identifiers

PMID41899393

DOI10.3390/cimb48030240

PMCPMC13025569

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.