Evidence map›Paper›PMID 41899134›Full record

ArticleJournal of clinical medicine2026

Switching to High-Dose Aflibercept (8 mg) with Pro Re Nata Reduces Treatment Burden in Diabetic Macular Edema: A Real-World Pilot Study.

Masahiko Funatsu, Fumiaki Higashijima, Nobuaki Ariyoshi, Aiko Haraguchi, Yuki Wasai, Masanori Mikuni, Manami Ohta, Makiko Wakuta, Shinji Hirano, Kazuhiko Yamauchi and 1 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masahiko FunatsuDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Fumiaki HigashijimaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0002-3428-852X
Nobuaki AriyoshiDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Aiko HaraguchiDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Yuki WasaiDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Masanori MikuniDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Manami OhtaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Makiko WakutaDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0002-9910-770X
Shinji HiranoDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Kazuhiko YamauchiYamaguchi Red Cross Hospital, Yamaguchi 753-0092, Yamaguchi, Japan.
Kazuhiro KimuraDepartment of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

aflibercept 8 mganti-VEGF therapydiabetic macular edemainjection frequencyPRNpro re natareal-world evidencetreatment switching

Identifiers

PMID41899134
PMCPMC13027087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.