Evidence map›Paper›PMID 41898875›Full record

ArticleGenes2026

Frequency and Hearing Loss Phenotypes of

Masayuki Kawakita, Hideaki Moteki, Shin-Ya Nishio, Yumiko Kobayashi, Mika Adachi, Takayuki Okano, Hiroshi Yamazaki, Jun Nakayama, Shinya Ohira, Takashi Ishino and 2 more

Abstract read
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masayuki KawakitaDepartment of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Hideaki MotekiDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0003-0567-8278
Shin-Ya NishioDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0001-6640-2297
Yumiko KobayashiDepartment of Clinical Genetics, Iwate Medical University, Morioka 020-8505, Japan.ORCID 0009-0001-7177-4949
Mika AdachiDepartment of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital, Sendai 980-8574, Japan.
Takayuki OkanoDepartment of Otolaryngology-Head and Neck Surgery, Fujita Health University, Toyoake 470-1192, Japan.
Hiroshi YamazakiDepartment of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Jun NakayamaDepartment of Otorhinolaryngology-Head and Neck Surgery, Shiga University of Medical Science, Otsu 520-2192, Japan.
Shinya OhiraDepartment of Otorhinolaryngology, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.
Takashi IshinoDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0002-0646-0839
Yutaka TakumiDepartment of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Shin-Ichi UsamiDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-5068-6122

Funding

Japan Agency for Medical Research and Development JP16kk0205010, JP18ek0109363, JP21ek0109542, and JP24ek0109741Ministry of Health, Labor and Welfare of Japan H29-Nanchitou(Nan)-Ippan-031, 20FC10148, 23FC10149
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe

methodsA total of 18,475 Japanese patients with hearing loss were recruited. Targeted massively parallel sequencing of 158 deafness-related genes was performed, and individuals with

resultsTen individuals from eight independent families carrying

conclusions

Indexed as

GTP PhosphohydrolasesHearing LossHearing Loss, CentralOptic Atrophy, Autosomal DominantAdolescentAdultAgedChildChild, PreschoolFemaleGenetic Association StudiesHumansMaleMiddle AgedMutationMutation, MissenseGTP PhosphohydrolasesOPA1 protein, humanauditory neuropathy spectrum disordercochlear implantdominant optic atrophyOPA1syndromic hearing loss

Identifiers

PMID41898875
PMCPMC13025685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.