Evidence map›Paper›PMID 41898861›Full record

ArticleGenes2026

Transcriptional Activation of Estrogen Receptor-Alpha and Estrogen Receptor-Beta from Elephant Shark (

Ya Ao, Haruka Narita, Wataru Takagi, Susumu Hyodo, Michael E Baker, Yoshinao Katsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ya AoGraduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.ORCID 0009-0005-1187-1607
Haruka NaritaGraduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Wataru TakagiLaboratory of Physiology, Atmosphere and Ocean Research Institute, The University of Tokyo, Chiba 277-8564, Japan.ORCID 0000-0002-7882-0223
Susumu HyodoLaboratory of Physiology, Atmosphere and Ocean Research Institute, The University of Tokyo, Chiba 277-8564, Japan.
Michael E BakerDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.ORCID 0000-0003-4387-3269
Yoshinao KatsuGraduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.ORCID 0000-0003-2625-4626

Funding

Ministry of Education, Culture, Sports, Science and Technology of Japan 23K05839Takeda Science Foundation none
6 · The paper itself

Abstract

BACKGROUND/

objectivesHumans and other vertebrates contain two estrogen receptors (ERs), ERa and ERb. Among cartilaginous fish (sharks, rays, skates), which are chondrichthyans that evolved about 425 million years ago, only activation by steroids of ERb orthologs has been characterized. To remedy this gap in understanding estrogen signaling in chondrichthyans, we studied estrogen activation of orthologs of human ERa and ERb from elephant shark ( METHODS/

resultsUnexpectedly, we found that

conclusionsOverall, estrogen activation of

Indexed as

Estrogen Receptor alphaEstrogen Receptor betaFish ProteinsSharksTranscriptional ActivationAmino Acid SequenceAnimalsEstradiolEstrogensFemaleHumansPhylogenyEstradiolEstrogen Receptor alphaEstrogen Receptor betaEstrogensFish Proteinselephant sharkERaERbestrogen receptor evolution

Identifiers

PMID41898861
PMCPMC13026664

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.