Direct Production of 2-Butanol from Glucose by Recombinant

Emanoel Gergov, Alexander Arsov, Kaloyan Petrov, Lidia Tsigoriyna, Penka Petrova

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emanoel GergovInstitute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

Alexander ArsovInstitute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-4733-9530

Kaloyan PetrovInstitute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-9197-0894

Lidia TsigoriynaInstitute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

Penka PetrovaInstitute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-7356-5799

Funding

The National Scientific Fund, Republic of Bulgaria KP-06-N67/11

6 · The paper itself

Abstract

2-Butanol is a promising biofuel due to its favorable properties and lower microbial toxicity compared to other butanol isomers. However, microbial production remains challenging due to the absence of a native biochemical pathway for directly converting sugars into 2-butanol. To achieve this goal, glucose should be directed through the 2,3-butanediol (2,3-BD) pathway, involving α-acetolactate synthase, α-acetolactate decarboxylase, and butanediol dehydrogenase for the formation of meso-2,3-BD, followed by diol dehydratase-catalyzed conversion of meso-2,3-BD to butanone and alcohol dehydrogenase-mediated reduction in butanone to 2-butanol. In this study, we report the development of six new recombinant strains based on

Indexed as

ButanolsGlucoseKlebsiella pneumoniaeButylene GlycolsHydro-LyasesMetabolic Engineering2,3-butylene glycol2-butanolButanolsButylene GlycolsGlucoseHydro-Lyases2-butanolalcohol dehydrogenaseClostridium beijerinckiidiol dehydrataseKlebsiella pneumoniaeLentilactobacillus diolivorans

Identifiers

PMID41898751

DOI10.3390/ijms27062892

PMCPMC13026961

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.