Constructing Curcumin-Based Biological Metal-Organic Frameworks (MOFs) for the Treatment of Alzheimer's Disease Through the Pyroptosis Pathway.

Fanshu Sun, Kangning Liu, Enpeng Xi, Yun Zhao, Nan Gao

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Fanshu SunKey Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.

Kangning LiuKey Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.

Enpeng XiKey Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.ORCID 0009-0004-6399-1398

Yun ZhaoKey Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.ORCID 0009-0002-8845-5546

Nan GaoKey Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.ORCID 0000-0001-7700-1544

Funding

National Key R&D Program of China 2022YFB3805902National Natural Science Foundation of China 22077118the "111" project B18012

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder that presents as neuronal cell death caused by the pyroptosis pathway. Currently, curcumin is widely reported in the treatment of AD due to its dual inhibitory effects on NLRP3-associated inflammasome activation, but it suffers from poor bioavailability. Therefore, in this study, a highly stable curcumin-based Zn-organic framework (medi-MOF-1) loaded with taxifolin (TAX@medi-MOF-1) was presented to overcome the defect with a specific surface area of 2530.652 m

Indexed as

Alzheimer DiseaseCurcuminMetal-Organic FrameworksPyroptosisAnimalsAntioxidantsCaspase 1HumansMiceMice, TransgenicNLR Family, Pyrin Domain-Containing 3 ProteinQuercetinAntioxidantsCaspase 1CurcuminMetal-Organic FrameworksNLR Family, Pyrin Domain-Containing 3 ProteinQuercetintaxifolinAlzheimer’s diseasecurcuminpyroptosistaxifolinZn–organic framework

Identifiers

PMID41898738

DOI10.3390/ijms27062871

PMCPMC13026492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.