Evidence map›Paper›PMID 41898673›Full record

ArticleInternational journal of molecular sciences2026

Kappa-Opioid Receptor Antagonism Prolongs the Antidepressant Effects of Ketamine in Adult Mice with Depression-like Behavior Induced by Adolescent Chronic Unpredictable Stress.

Ana Zivanovic, Milos Mitic, Iva Lukic, Emilija Glavonic, Miroslav Adzic, Sanja Ivkovic

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana ZivanovicVinca-Institute for Nuclear Sciences, National Institute of Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.ORCID 0009-0009-7112-0169
Milos MiticVinca-Institute for Nuclear Sciences, National Institute of Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.ORCID 0000-0002-3849-6561
Iva LukicVinca-Institute for Nuclear Sciences, National Institute of Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.ORCID 0000-0002-5334-5702
Emilija GlavonicVinca-Institute for Nuclear Sciences, National Institute of Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.ORCID 0000-0002-2053-7716
Miroslav AdzicVinca-Institute for Nuclear Sciences, National Institute of Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.ORCID 0000-0003-4234-7275
Sanja IvkovicVinca-Institute for Nuclear Sciences, National Institute of Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.ORCID 0000-0002-7977-3166

Funding

Ministry of Education, Science and Technological Development, Republic of Serbia 451-03-33/2026-03/ 200017
6 · The paper itself

Abstract

Major depressive disorder (MDD) is a highly prevalent psychiatric illness for which rapid-acting antidepressants such as ketamine provide only transient benefit. Because κ-opioid receptor (KOR) signaling contributes to stress-related dysphoria and impaired neuroplasticity, we examined whether KOR antagonism could prolong ketamine's antidepressant-like effects in a mouse model of adolescent chronic unpredictable stress (CUS). Male

Indexed as

Antidepressive AgentsDepressionKetamineNaltrexoneNarcotic AntagonistsReceptors, Opioid, kappaStress, PsychologicalAnimalsBehavior, AnimalBrain-Derived Neurotrophic FactorDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLPrefrontal CortexAntidepressive AgentsBrain-Derived Neurotrophic FactorKetamineNaltrexoneNarcotic AntagonistsnorbinaltorphimineReceptors, Opioid, kappachronic unpredictable stress (CUS)depressionketaminenorbinaltorphimine (nBNI)κ-opioid receptor (KOR)

Identifiers

PMID41898673
PMCPMC13026322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.