Evidence map›Paper›PMID 41898621›Full record

ArticleInternational journal of molecular sciences2026

Left Ventricular and Right Ventricular Hypertrophy Modelling to Study PAPP-A-Mediated IGFBP-4 Cleavage-a Mechanism That Regulates IGF Bioavailability in Adult Rats.

Marina M Artemieva, Arina V Makeeva, Daria A Adasheva, Viacheslav E Shein, Alexey G Katrukha, Alexander B Postnikov, Natalia A Medvedeva, Daria V Serebryanaya

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marina M ArtemievaSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Arina V MakeevaSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Daria A AdashevaSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.ORCID 0009-0005-0051-7303
Viacheslav E SheinSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Alexey G KatrukhaSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Alexander B PostnikovHyTest, Ltd., 20520 Turku, Finland.
Natalia A MedvedevaSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Daria V SerebryanayaSchool of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.

Funding

Russian State Foundation Grant 24-25-00051
6 · The paper itself

Abstract

Pathological cardiac hypertrophy, a major contributor to heart failure, is characterized by an abnormal increase in the size of atria and ventricles. In the context of ventricular hypertrophy, the right ventricle (RV) exhibits less resistance to hypertrophy than the left one (LV). Insulin-like growth factors (IGF-1 and IGF-2) are critical for cell growth and provide cardioprotective effects. Pregnancy-associated plasma protein-A (PAPP-A) is a protease that cleaves insulin-like growth factor-binding protein-4 (IGFBP-4) and enhances IGF bioavailability. This study investigated PAPP-A-mediated IGFBP-4 proteolysis-one possible mechanism of IGF release regulation in rat models of right ventricular (RVH) and left ventricular (LVH) hypertrophy. RVH was induced with monocrotaline, and LVH via renovascular hypertension (1 Kidney 1 Clip (1K1C) model). Systolic blood pressure was measured using tail-cuff plethysmography. Heart morphometry was used to assess the mass of cardiac chambers. Cardiomyocyte purity was confirmed via troponin I immunocytochemistry. Plasma natriuretic type-B peptide (BNP) and C-terminal IGFBP-4 (CT-IGFBP-4) concentrations were quantified by fluoroimmunoassay. RVH and LVH were successfully modelled, with 1.6-fold and 1.3-fold increases in RV (

Indexed as

Hypertrophy, Left VentricularHypertrophy, Right VentricularInsulin-Like Growth Factor Binding Protein 4Insulin-Like Growth Factor IInsulin-Like PeptidesPregnancy-Associated Plasma Protein-AAnimalsDisease Models, AnimalHeart VentriclesMaleMyocytes, CardiacProteolysisRatsRats, Sprague-DawleyInsulin-Like Growth Factor Binding Protein 4Insulin-Like Growth Factor IInsulin-Like PeptidesPregnancy-Associated Plasma Protein-Acardiac hypertrophyPAPP-A-mediated IGFBP-4 proteolysispulmonary hypertensionrenovascular hypertension

Identifiers

PMID41898621
PMCPMC13026115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.