Synthesis and Auxin-like Activity of Halogenated Alkylphenoxyacetic Acids.

Stepan V Vorobyev, Danila V Mizin, Maria A Breygina, Ekaterina A Bykova, Maxim E Antropov, Boris P Tonkonogov, Vladimir N Koshelev

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Stepan V VorobyevDepartment of Organic Chemistry and Petroleum Chemistry, Faculty of Chemical and Environmental Engineering, Gubkin University, Leninsky Prospect 65, Moscow 119991, Russia.ORCID 0000-0001-6042-6394

Danila V MizinDepartment of Organic Chemistry and Petroleum Chemistry, Faculty of Chemical and Environmental Engineering, Gubkin University, Leninsky Prospect 65, Moscow 119991, Russia.ORCID 0009-0008-8923-2583

Maria A BreyginaDepartment of Plant Physiology, Biological Faculty, Lomonosov Moscow State University, Leninskiye Gory 1-12, Moscow 119234, Russia.ORCID 0000-0002-0588-6731

Ekaterina A BykovaDepartment of Plant Physiology, Biological Faculty, Lomonosov Moscow State University, Leninskiye Gory 1-12, Moscow 119234, Russia.

Maxim E AntropovDepartment of Organic Chemistry and Petroleum Chemistry, Faculty of Chemical and Environmental Engineering, Gubkin University, Leninsky Prospect 65, Moscow 119991, Russia.ORCID 0009-0003-6486-2398

Boris P TonkonogovDepartment of Chemistry and Technology of Lubricants and Chemometology, Faculty of Chemical and Environmental Engineering, Gubkin University, Leninsky Prospect 65, Moscow 119991, Russia.

Vladimir N KoshelevDepartment of Organic Chemistry and Petroleum Chemistry, Faculty of Chemical and Environmental Engineering, Gubkin University, Leninsky Prospect 65, Moscow 119991, Russia.

Funding

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6 · The paper itself

Abstract

Synthetic auxins are widely used nowadays as plant growth regulators and necessary components of media for micropropagation. Hence, the search for and development of novel auxin-like compounds is an important goal at the intersection of chemistry and biology. In this study, we have suggested alkylphenols as starting materials for the preparation of halogenated phenoxyacetic acids, which are well-known synthetic auxins, to decrease their possible phytotoxicity. Alkylphenoxyacetic acids were obtained with good yields, and their selective halogenation was studied. N-halogensuccinimides and molecular bromine in dioxane were shown as suitable reagents since they allowed for

Indexed as

Indoleacetic AcidsPlant Growth RegulatorsAcetatesGerminationHalogenationNicotianaPollenSeedlingsSeedsZea maysAcetatesIndoleacetic Acidsphenoxyacetic acidPlant Growth RegulatorsalkylphenolsDFT calculationsphenoxyacetic acidsplant growth regulationplant hormonespollen germinationseed germinationselective halogenationsynthetic auxins

Identifiers

PMID41898557

DOI10.3390/ijms27062696

PMCPMC13026768

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