Evidence map›Paper›PMID 41898541›Full record

ArticleInternational journal of molecular sciences2026

EDIL3/Del-1-Dependent Induction of AMPKβ Phosphorylation Regulates the Progression of Mesenchymal Stem-like Triple-Negative Breast Cancer.

Seol-Hwa Jeong, Soo Jung Lee, In Hee Lee, Jeeyeon Lee, Byeongju Kang, Joon Suk Moon, Ho Yong Park, Ji Young Park, Nora Jee Young Park, Eun Ae Kim and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seol-Hwa JeongCell & Matrix Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0009-0004-7280-0127
Soo Jung LeeDepartment of Oncology/Hematology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0000-0003-0066-4109
In Hee LeeDepartment of Oncology/Hematology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.
Jeeyeon LeeDepartment of Breast Surgery, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0000-0003-1826-1690
Byeongju KangDepartment of Breast Surgery, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0000-0002-3589-5559
Joon Suk MoonDepartment of Breast Surgery, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0009-0009-2880-6472
Ho Yong ParkDepartment of Breast Surgery, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.
Ji Young ParkDepartment of Pathology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0000-0002-7571-1064
Nora Jee Young ParkDepartment of Pathology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0000-0002-1857-813X
Eun Ae KimBreast Cancer Precision Medicine Institute, Kyungpook National University Chilgok Hospital, Daegu 40405, Republic of Korea.ORCID 0000-0002-7639-8962
Jieun KangBreast Cancer Precision Medicine Institute, Kyungpook National University Chilgok Hospital, Daegu 40405, Republic of Korea.ORCID 0000-0003-3976-6655
Yee Soo ChaeDepartment of Oncology/Hematology, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea.ORCID 0000-0002-8585-4982

Funding

Korea Health Industry Development Institute HR-2022-KH130591Ministry of Education RS-2024-00450853
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and the mechanisms by which developmental endothelial locus-1 (EDIL3/Del-1) promotes TNBC remain incompletely defined. We profiled Del-1 and AMPK subunits in TNBC cell lines by RT-PCR and immunoblotting, performed functional assays in CRISPR/Cas9 Del-1 knockout and AMPKβ-manipulated cells, and evaluated AMPKβ in early-stage TNBC tumors using tissue microarrays (TMA) (immunohistochemistry;

Indexed as

AMP-Activated Protein KinasesMesenchymal Stem CellsMicrofilament ProteinsTriple Negative Breast NeoplasmsAnimalsCalcium-Binding ProteinsCell Adhesion MoleculesCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMicePhosphorylationAMP-Activated Protein KinasesCalcium-Binding ProteinsCell Adhesion MoleculesEDIL3 protein, humanMicrofilament ProteinsAMP-activated protein kinase β subunitDel-1EDIL3triple-negative breast cancer

Identifiers

PMID41898541
PMCPMC13026944

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.