Evidence map›Paper›PMID 41898519›Full record

ArticleInternational journal of molecular sciences2026

Rong Bu, Wael Haqawi, Eman A Abdul Razzaq, Saud Azam, Kaleem Iqbal, Zeeshan Qadri, Sandeep Kumar Parvathareddy, Maha Alrasheed, Khadija Alobaisi, Fouad Al-Dayel and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rong BuGenomic Analytics, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Wael HaqawiGenomic Analytics, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Eman A Abdul RazzaqTranslational Oncology Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Saud AzamHuman Cancer Genomic Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-8091-5280
Kaleem IqbalGenomic Analytics, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0001-5634-5030
Zeeshan QadriHuman Cancer Genomic Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Sandeep Kumar ParvathareddyHuman Cancer Genomic Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Maha AlrasheedHuman Cancer Genomic Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Khadija AlobaisiTranslational Oncology Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Fouad Al-DayelAnatomic Pathology Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Abdul Khalid SirajTranslational Oncology Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Khawla S Al-KurayaHuman Cancer Genomic Research, Research Laboratories, Innovation and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-4126-3419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary thyroid cancer (PTC) is the most common endocrine malignancy with especially high incidence in Middle Eastern populations. While classical hereditary syndromes explain a minority of cases, the broader germline landscape of non-syndromic PTC remains unclear. Whole-exome sequencing was performed on 245 unselected Saudi PTC patients to identify germline pathogenic or likely pathogenic variants (PVs/LPVs) in cancer predisposition genes. Clinical and molecular characteristics, and family history were integrated to assess phenotypic correlations. Eleven patients (4.5%) harbored germline PVs/LPVs in cancer susceptibility genes including

Indexed as

DNA RepairProtein Serine-Threonine KinasesThyroid Cancer, PapillaryThyroid NeoplasmsAdultAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesExome SequencingFemaleGenetic Predisposition to DiseaseGerm-Line MutationHumansMaleMiddle AgedSaudi ArabiaAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesProtein Serine-Threonine KinasesSTK11 protein, humancancer predisposition genesDNA repair genesexome sequencinggermline mutationspapillary thyroid cancerSaudi Arabia

Identifiers

PMID41898519
PMCPMC13026885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.