Evidence map›Paper›PMID 41898503›Full record

ArticleInternational journal of molecular sciences2026

Discovery of Novel Molecular Scaffolds to Overcome

Francesco Iesce, Jochem Nelen, Alejandro Rodríguez-Martínez, Carlos Martínez-Cortés, Cristina Minnelli, Giovanna Mobbili, Alessandra Di Gregorio, Carla Vignaroli, Horacio Pérez-Sánchez, Roberta Galeazzi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesco IesceDepartment of Life and Environmental Sciences, Polytechnic University of Marche, via Brecce Bianche, 60131 Ancona, Italy.ORCID 0009-0000-3829-3804
Jochem NelenStructural Bioinformatics and High Performance Computing Research Group (BIO-HPC), HiTech Innovation Hub, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.ORCID 0000-0002-9970-4950
Alejandro Rodríguez-MartínezStructural Bioinformatics and High Performance Computing Research Group (BIO-HPC), HiTech Innovation Hub, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.
Carlos Martínez-CortésStructural Bioinformatics and High Performance Computing Research Group (BIO-HPC), HiTech Innovation Hub, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.
Cristina MinnelliDepartment of Life and Environmental Sciences, Polytechnic University of Marche, via Brecce Bianche, 60131 Ancona, Italy.ORCID 0000-0001-8034-8557
Giovanna MobbiliDepartment of Life and Environmental Sciences, Polytechnic University of Marche, via Brecce Bianche, 60131 Ancona, Italy.ORCID 0000-0003-0243-5844
Alessandra Di GregorioDepartment of Life and Environmental Sciences, Polytechnic University of Marche, via Brecce Bianche, 60131 Ancona, Italy.
Carla VignaroliDepartment of Life and Environmental Sciences, Polytechnic University of Marche, via Brecce Bianche, 60131 Ancona, Italy.ORCID 0000-0002-0993-5967
Horacio Pérez-SánchezStructural Bioinformatics and High Performance Computing Research Group (BIO-HPC), HiTech Innovation Hub, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.ORCID 0000-0003-4468-7898
Roberta GaleazziDepartment of Life and Environmental Sciences, Polytechnic University of Marche, via Brecce Bianche, 60131 Ancona, Italy.ORCID 0000-0003-1792-654X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The berberine derivative 13-(2-methylbenzyl)-berberine (BED) has been shown to inhibit the MexXY-OprM efflux system of

Indexed as

AminoglycosidesAnti-Bacterial AgentsDrug Resistance, BacterialPseudomonas aeruginosaBacterial ProteinsBinding SitesDrug DesignLigandsMembrane Transport ProteinsMolecular Docking SimulationMolecular Dynamics SimulationPharmacophoreAminoglycosidesAnti-Bacterial AgentsBacterial ProteinsLigandsMembrane Transport Proteinsefflux pump inhibitorsligand-based virtual screeningmulti-drug resistancepharmacophore modelPseudomonas aeruginosascaffold hopping

Identifiers

PMID41898503
PMCPMC13026256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.