ArticleInternational journal of molecular sciences2026
Genotype-Encoded UV Sensitivity in iPSC-Derived Human Melanocytes Reveals MX2 as a Physiological Amplifier of p53/p38-Mediated DNA Damage Signaling.
Eric Ramirez-Salazar, Ana Slipicevic, Marina Juraleviciute, Ling Li, Mark Harland, Sally O'Shea, Sinead Field, Julia Newton-Bishop, Meenhard Herlyn
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Marina JuraleviciuteDepartment of Pathology, Oslo University Hospital, Norwegian Radium Hospital, 0379 Oslo, Norway.
Ling LiThe Wistar Institute, Philadelphia, PA 19104, USA.
Mark HarlandLeeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds LS2 9JT, UK.
Sally O'SheaLeeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds LS2 9JT, UK.ORCID 0000-0002-1588-6022 Sinead FieldLeeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds LS2 9JT, UK.
Julia Newton-BishopLeeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds LS2 9JT, UK.
Meenhard HerlynThe Wistar Institute, Philadelphia, PA 19104, USA.
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9MResearch Project 2 - Targeting Melanoma Tumor Survival and Apoptotic MachineryU54CA224070 · NCI · WISTAR INSTITUTE · PI Meenhard F Herlyn · 2017 to 2026
$13.9MGamma delta T cell based melanoma therapiesR01CA258113 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Meenhard F Herlyn, Xiaowei Xu · 2022 to 2026
$3.3MDissecting Phenotype Switching in Early Stage MelanomasR01CA259295 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Meenhard F Herlyn, Markus Schober · 2022 to 2026
$3.1MCancer Research UK C588/A10721Cancer Research UK C588/A19167Cancer Research UK C8216/A6129NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA258113NCI NIH HHS R01 CA259295NCI NIH HHS U54 CA224070NIH, USA SPORE P50 CA174523
6 · The paper itselfAbstract
Ultraviolet (UV) radiation induces DNA damage and oxidative stress in melanocytes, shaping pigmentation phenotypes and elevating photocarcinogenesis risk. Human models that capture donor-linked genetic determinants of UV sensitivity remain limited. Here, we establish a genotype-informed UV response model using induced pluripotent stem cell (iPSC)-derived melanocytes from donors carrying defined
Indexed as
DNA DamageInduced Pluripotent Stem CellsMelanocytesMyxovirus Resistance Proteinsp38 Mitogen-Activated Protein KinasesTumor Suppressor Protein p53Ultraviolet RaysApoptosisCell DifferentiationGenotypeHumansSignal TransductionMyxovirus Resistance Proteinsp38 Mitogen-Activated Protein KinasesTP53 protein, humanTumor Suppressor Protein p53DNA damage responseinduced pluripotent stem cellsiPSC-derived melanocytesMC1R variantsMX2new approach methodologiesp53 signalingultraviolet radiation
Identifiers
PMID41898480
PMCPMC13027049
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