BDNF and TNF-α, OCT and VF Parameters in Pituitary Macroadenoma Patients: A 12-Month Prospective Study.

Monika Sarnat-Kucharczyk, Beata Kos-Kudła, Małgorzata A Janik, Paweł Janik, Katarzyna Komosińska-Vassev, Aleksandra Górecka, Ewa Mrukwa-Kominek

Abstract readObservational Study

PubMed Full text at PMC Publisher

In one paragraph

Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Monika Sarnat-KucharczykDepartment of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.ORCID 0000-0001-7826-2906

Beata Kos-KudłaKornel Gibinski University Clinical Centre, Medical University of Silesia, 40-514 Katowice, Poland.ORCID 0000-0003-3755-1722

Małgorzata A JanikInstitute of Biomedical Engineering, Faculty of Science and Technology, University of Silesia in Katowice, 41-205 Sosnowiec, Poland.ORCID 0000-0001-5489-4220

Paweł JanikInstitute of Biomedical Engineering, Faculty of Science and Technology, University of Silesia in Katowice, 41-205 Sosnowiec, Poland.ORCID 0000-0003-0910-3578

Katarzyna Komosińska-VassevDepartment of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.ORCID 0000-0003-2307-5884

Aleksandra GóreckaDepartment of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.ORCID 0000-0002-9818-9221

Ewa Mrukwa-KominekDepartment of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.

Funding

Medical University of Silesia PCN-1-080/N/2/K

6 · The paper itself

Abstract

Pituitary macroadenomas often cause visual pathway impairment due to optic chiasm compression. The association between systemic neurotrophic factors and visual recovery remains insufficiently explored. This prospective observational cohort study included 53 patients (106 eyes); 36 patients (72 eyes) completed a 12-month follow-up. Patients were assigned to a treatment group (surgical and/or pharmacological;

Indexed as

AdenomaBrain-Derived Neurotrophic FactorPituitary NeoplasmsTumor Necrosis Factor-alphaVisual FieldsAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesTomography, Optical CoherenceBDNF protein, humanBrain-Derived Neurotrophic FactorTumor Necrosis Factor-alphabrain-derived neurotrophic factor (BDNF)optical coherence tomographypituitary macroadenomastumor necrosis factor alpha (TNF-α)visual field

Identifiers

PMID41898472

DOI10.3390/ijms27062609

PMCPMC13026532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.