Mechanisms of Programmed Cell Death in Sodium Iodate-Driven Retinal Degeneration and the Role of DJ-1.

Mala Upadhyay, Caroline Milliner, Vera L Bonilha

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Arsenic exposure promotes retinal pigment epithelium dysfunction and oxidative stress via NF-κB pathway.Scientific reports · 2026
Article
Platelet-neutrophil niches associate with epidermal immune activation and systemic inflammation in psoriatic disease.Journal of molecular medicine (Berlin, Germany) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mala UpadhyayDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0002-0591-6515

Caroline MillinerDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0002-2467-7150

Vera L BonilhaDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0002-6166-5124

Funding

Cleveland Clinic Founda- 626 tion startup fundsCleveland Eye Bank Foundation N/ADale and Lois Marks & Family N/ANIH HHS P30EY025585 and RO1EY027750Research to Prevent Blindness unrestricted grantTimken Foundation N/A

6 · The paper itself

Abstract

Oxidative stress-induced RPE cell death is a major cause of AMD pathogenesis. However, the exact modes of oxidative stress-driven retinal death remain elusive. To address this knowledge gap, we investigated the role of DJ-1, an antioxidant protein we previously characterized in the retina, in cell death regulation. Specifically, we analyzed cell death pathways in the retinas of DJ-1 knockout (KO) mice, with or without sodium iodate (NaIO

Indexed as

ApoptosisIodatesProtein Deglycase DJ-1Retinal DegenerationAnimalsCaspase 3MiceMice, Inbred C57BLMice, KnockoutOxidative StressRetinaRetinal Pigment EpitheliumCaspase 3IodatesPARK7 protein, mouseProtein Deglycase DJ-1sodium iodateapoptosisDJ-1necroptosisretinaRPEsodium iodate

Identifiers

PMID41898405

DOI10.3390/ijms27062541

PMCPMC13026112

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.