ReviewBiomedicines2026
The Mechanism of Ferroptosis and Blood-Brain Barrier Damage in Cerebrovascular Diseases.
Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Targeting ferroptosis and oxidative stress crosstalk: a new frontier in stroke neuroprotection.Journal of molecular histology · 2026Review
- Endothelial ferroptosis in blood-brain barrier dysfunction and neuroinflammation: mechanisms and immune-vascular crosstalk.Frontiers in immunology · 2026Review
- Periodontitis and Alzheimer's disease, common pathways in down syndrome.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blood-brain barrier (BBB) is a vital protective structure that prevents harmful substances in the blood from entering the central nervous system while maintaining homeostasis. Its dysfunction can lead to significant pathological changes and contribute to various neurological disorders, such as stroke and neurodegenerative diseases. BBB damage of varying degrees is observed in nearly all cerebrovascular diseases, yet the specific mechanisms remain largely unclear. Growing evidence indicates that ferroptosis-an iron-dependent, lipid peroxidation-driven form of regulated cell death-is a major pathway contributing to BBB disruption. Ferroptosis affects multiple key brain cell types, including endothelial cells, glial cells, pericytes, and neurons, potentially leading to BBB dysfunction in cerebrovascular diseases. This article explores the role of ferroptosis in different types of cerebrovascular diseases and its effects on various cells. It covers the latest research in this area and highlights the potential benefits of targeting ferroptosis, including protecting the blood-brain barrier, reducing neuroinflammation, and protecting neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.