Evidence map›Paper›PMID 41897935›Full record

ArticleAnimals : an open access journal from MDPI2026

miRNA-146b Targets

Yangyang Song, Peng Liu, Mingxue Li, Xiaolin Li, Huaxue Song, Yutong Zhang, Fanzhi Kong, Changyuan Wang, Binglei Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yangyang SongCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Peng LiuCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Mingxue LiCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Xiaolin LiCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Huaxue SongCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Yutong ZhangCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Fanzhi KongCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.ORCID 0000-0003-2872-0088
Changyuan WangCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Binglei ShenCollege of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mastitis is an inflammatory disease of mammary tissue that impairs milk production and quality, thereby seriously threatening the economic viability of dairy farms. miRNAs, such as miR-146b, are emerging as new candidates for anti-inflammatory therapy, and their activity modulation may provide a basis for controlling inflammation. However, the exact role and underlying mechanisms of miR-146b in bovine mastitis and associated inflammatory pathways in bovine mammary epithelial cells are still unclear. To clarify this, we established an in vitro model by stimulating MAC-T cells with Lipoteichoic acid and investigated the miR-146b-associated molecular pathways. The data from this study showed increased miR-146b expression after LTA stimulation. Then, the dual-luciferase reporter assay identified

Indexed as

inflammationMAC-T cellsmastitismiR-146b

Identifiers

PMID41897935
PMCPMC13023339

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.