Short-Chain Fatty Acids Regulate Poultry Feed Intake via the Hypothalamus: Receptor-Mediated and Epigenetic Mechanisms.

Yanli Wang, Xueqing Xiao, Bo Zheng, Dongying Bai, Yi Zhang, Wenrui Zhen, Bingkun Zhang, Yanbo Ma

Abstract readReview

In one paragraph

Review in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Dietary fermented orange peel and selenium nanoparticles improve antioxidant status, immunity, intestinal integrity, and growth performance in heat-stressed broilers.Poultry science · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanli WangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.

Xueqing XiaoDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.

Bo ZhengDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.ORCID 0009-0009-3264-738X

Dongying BaiDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.

Yi ZhangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.ORCID 0000-0002-4773-287X

Wenrui ZhenDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.ORCID 0000-0002-3433-8398

Bingkun ZhangState Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

Yanbo MaDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.

Funding

Financial support statement National Key Research and Development Program of China #2024YFE0111600Key Research and Development Program of Henan Province #241111113800the Frontier exploration Projects of Longmen Laboratory # LMQYTSKT037Trendy Industry Projects of Longmen Laboratory #LMFKCY2023002

6 · The paper itself

Abstract

The global poultry industry faces escalating challenges in animal welfare and production efficiency in the post-antibiotic era. Feed intake, a crucial determinant of growth, is frequently suppressed under stress, forming a key bottleneck for sustainable production. The microbiota-gut-brain (MGB) axis provides a novel framework to understand this complex regulation. Short-chain fatty acids (SCFAs), produced from dietary fiber by gut microbiota, serve as vital chemical messengers within this axis, modulating hypothalamic feeding centers and systemic metabolism. This review summarizes SCFA biosynthesis and kinetics in poultry and examines their neural, humoral, and immune pathways to the brain. Emphasis is placed on receptor-mediated signaling, epigenetic regulation, energy sensing, and neuroimmune modulation through which SCFAs regulate feeding and reduce inflammation. Practical strategies-such as substrate engineering, microbiota modulation, and exogenous regulators-are discussed to enhance SCFA levels and poultry health. Future directions include multi-omics integration, novel additives, and predictive models to advance antibiotic-free nutrition.

Indexed as

feed intake regulationhypothalamusmicrobiota–gut–brain axisneuroimmunitypoultry nutritionprecision feedingshort-chain fatty acids

Identifiers

PMID41897931

DOI10.3390/ani16060954

PMCPMC13023304

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.