Evidence map›Paper›PMID 41897913›Full record

ArticleAnimals : an open access journal from MDPI2026

Shotgun Metagenomics Reveals Gut Microbiome Remodeling with Altered Taxonomic Composition and Functional Potential in Diabetic Dogs.

Qi An, Siyu Chen, Shizhen Ma, Rina Bai, Zijie Lu, Yang Liu, Fan Wang, Qian Wang, Yu Song, Gege Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qi AnCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0009-0001-9123-2936
Siyu ChenCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Shizhen MaState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130015, China.
Rina BaiCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Zijie LuVeterinary Teaching Hospital, China Agricultural University, Beijing 100193, China.
Yang LiuVeterinary Teaching Hospital, China Agricultural University, Beijing 100193, China.
Fan WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Qian WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yu SongCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0009-0001-2094-9059
Gege ZhangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yanli LyuCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Lu WangKey Laboratory of Animal Antimicrobial Resistance Surveillance, Ministry of Agriculture and Rural Afairs, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-3259-3595
Yang WangKey Laboratory of Animal Antimicrobial Resistance Surveillance, Ministry of Agriculture and Rural Afairs, China Agricultural University, Beijing 100193, China.
Zhaofei XiaCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Funding

General Program of the 2025 Talent Fund, Veterinary Teaching Hospital, China Agricultural University 1051-2225006
6 · The paper itself

Abstract

Gut microbiota dysbiosis is implicated in metabolic disorders, yet taxonomic and functional alterations in canine diabetes remain incompletely defined. Here, we performed shotgun metagenomic sequencing of fecal samples from 38 diabetic dogs and 37 healthy controls under controlled conditions (no recent antibiotic/probiotic exposure and stable commercial diets). Alpha-diversity indices did not differ between groups, whereas beta-diversity revealed significant separation of community structure at both genus and species levels (

Indexed as

caninediabetes mellitusfecal microbiomeshotgun metagenomic sequencing

Identifiers

PMID41897913
PMCPMC13023283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.