Preparation and Identification of Corn-Derived Bioactive Peptides with Triple Efficacy of ADH-Activating, XOD-Inhibiting and Antioxidant Activity.

Zifan Yuan, Wenfei Zhang, Jiajie Chang, Yunlong Chen, Yinglian Zhu, Qi Wang, Qingli Yang

Abstract read

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Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Zifan YuanCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.

Wenfei ZhangCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.

Jiajie ChangCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.

Yunlong ChenCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.

Yinglian ZhuCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.

Qi WangCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.

Qingli YangCollege of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, China.ORCID 0000-0003-4732-6465

Funding

Qingdao City Science and Technology Benefits for the People Demonstration Project 202637Rural Revitalization Science, Technology Innovation Plan Project of Shandong Province 2022TZXD0031Special Funds of the Central Government for Guiding Local Scientific and Technological Development 24-1-4-5-zyyd-nshthe Special Foundation for Distinguished Taishan Scholar of Shandong Province tstp20230630

6 · The paper itself

Abstract

The health risks associated with excessive alcohol consumption have emerged as a public health challenge, with alcohol-associated liver disease (ALD) and hyperuricemia (HUA) being particularly prominent health issues. Current treatments often have side effects, driving the need for safe, multi-target natural alternatives. Based on the dual barrier strategy of "metabolic regulation-antioxidant defense", this study developed bioactive peptides from corn germ meal via enzymatic hydrolysis, which simultaneously activated alcohol dehydrogenase (ADH), inhibited xanthine oxidase (XOD), and exhibited antioxidative properties. The fraction <3 kDa emerged with stronger triple bioactivity while also demonstrating sensitivity to strong acids and enhanced activity under trypsin treatment in in vitro stability tests. A total of 841 unique peptides were obtained from purified peptide fractions. After computer-aided screening and molecular docking, three corn-derived peptides (LMFP, FEGLFR, and QLPSYR) were identified, which acted synergistically. Docking simulations revealed that they bind to ADH and XOD via hydrogen bonds and hydrophobic interactions, suggesting potential interactions with these enzymes that may influence their activity. The corn-derived bioactive peptides developed in this study may serve as potential resources for alleviating alcohol metabolism and hyperuricemia symptoms.

Indexed as

ADH activationantioxidationcomputer-aided screeningcorn peptidemolecular dockingXOD inhibition

Identifiers

PMID41897815

DOI10.3390/foods15061093

PMCPMC13025653

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.