Evidence map›Paper›PMID 41897780›Full record

ArticleFoods (Basel, Switzerland)2026

Screening of Phytotoxins in Raw Honey and the Honey Sugar Matrix's Modulatory Effects on Their Toxicity.

Liuqing Yang, Tian Xiao, Xin Yang, Li Yang, Wenjing Shen, Zihao Huang, Guang Nie, Conghui Dong, Xiue Jin, Qi Tang and 2 more

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liuqing YangNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China.
Tian XiaoCollege of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Xin YangGanzhou Forestry Science Research Institute, Ganzhou 341000, China.
Li YangCollege of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Wenjing ShenNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China.
Zihao HuangCollege of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Guang NieCollege of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Conghui DongNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China.
Xiue JinHubei Institute of Veterinary Drug Control, Wuhan 430000, China.
Qi TangCollege of Horticulture, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0003-2385-4263
Ying LuNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China.
Yajie ZhengNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China.ORCID 0000-0002-7777-2370

Funding

2024 Science and Technology Program of Ganzhou City GSKF (2024) 33A Project Supported by Scientific Research Fund of Hunan Provincial Education Department 23C0078A Project Supported by Scientific Research Fund of Hunan Provincial Education Department 25A0231Safety Assessment Program for Unknown Hazardous Factors and Known Hazardous Factors in Bee Products GJFP201601001the National Natural Science Foundation of China 31600238the National Natural Science Foundation of China 31871880
6 · The paper itself

Abstract

Honey, as a natural and nutritious sweetener, is one of the most widely consumed foods worldwide. However, the presence of phytotoxins in honey and the influence of honey's intrinsic sugar matrix on the toxicity of these phytotoxins remain insufficiently explored. An optimized liquid chromatography-quadrupole trap tandem mass spectrometry method was developed to quantify 17 toxic alkaloids in 150 raw honey samples. Camptothecin was identified for the first time in the tested samples and was the most prevalent contaminant (36% detection, max 3.09 μg/kg), which induced cardiac hypertrophy and impaired cardiac function in zebrafish assays. The honey sugar matrix further potentiated these adverse cardiac effects through exacerbating oxidative stress and upregulating pro-inflammatory and pro-apoptotic gene expression, while natural honey partially mitigated such damage by upregulating the key antioxidant gene

Indexed as

food safetyhoneyLC-MS/MSmatrix effectphytotoxins

Identifiers

PMID41897780
PMCPMC13025968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.