Evidence map›Paper›PMID 41897475›Full record

ArticleAntioxidants (Basel, Switzerland)2026

A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine.

Federico Abate, Elisabetta Schiano, Mariano Stornaiuolo, Fabrizia Guerra, Anna Terracciano, Gaetano Piccinocchi, Eugenio Caradonna, Fulvio Ferrara, Gian Carlo Tenore, Ettore Novellino

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federico AbateDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0009-0006-9372-0032
Elisabetta SchianoNGN Healthcare-New Generation Nutraceuticals s.r.l., Torrette Via Nazionale 207, 83013 Mercogliano, Italy.ORCID 0000-0002-8167-0334
Mariano StornaiuoloDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Naples, Italy.ORCID 0000-0003-2200-5083
Fabrizia GuerraNGN Healthcare-New Generation Nutraceuticals s.r.l., Torrette Via Nazionale 207, 83013 Mercogliano, Italy.
Anna TerraccianoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Naples, Italy.
Gaetano PiccinocchiComegen S.C.S., Società Cooperativa Sociale di Medici di Medicina Generale, Viale Maria Bakunin 41, 80125 Naples, Italy.ORCID 0000-0002-3095-2198
Eugenio CaradonnaIntegrated Laboratory Medicine Services, Centro Diagnostico Italiano S.p.A., 20011 Milan, Italy.ORCID 0000-0001-9729-6722
Fulvio FerraraDepartment of Experimental and Clinical Pathology, IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy.ORCID 0000-0002-5425-4335
Gian Carlo TenoreDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Naples, Italy.ORCID 0000-0002-0251-9936
Ettore NovellinoDepartment of Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-2181-2142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension remains a major global health challenge, and pharmacological therapy is often constrained by tolerability issues. Adjunctive approaches targeting the nitric oxide synthase and soluble guanylate cyclase-cyclic guanosine monophosphate (sGC-cGMP) pathway may offer additional benefits. This study investigated the efficacy and safety of a nutraceutical formulation combining grape pomace extract (Taurisolo

Indexed as

blood pressureclinical trialhypertensionL-argininenitric oxidenutraceuticaloxidative stresspolyphenols

Identifiers

PMID41897475
PMCPMC13023866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.