Evidence map›Paper›PMID 41897434›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Imbalance of Pro-Oxidant and Anti-Oxidant Biomarkers in Patients with Keratoconus.

Ariadna Patricia Nicula, Cristina Ariadna Nicula, Dorin Nicula, Karin Ursula Horvath, Camelia Manuela Mîrza, Paul Mihai Boarescu, Sorana D Bolboacă, Adriana-Elena Bulboacă

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Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ariadna Patricia NiculaMedical Informatics and Biostatistics, Department 11-Medical Education, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, Romania.
Cristina Ariadna NiculaOculens Clinic, Calea Turzii, No. 134, 400347 Cluj-Napoca, Romania.
Dorin NiculaOculens Clinic, Calea Turzii, No. 134, 400347 Cluj-Napoca, Romania.
Karin Ursula HorvathDepartment of Ophthalmology, "George Emil Palade" University of Medicine and Pharmacy Science and Technology, Márton Áron Str., No. 26, 540058 Târgu Mureș, Romania.
Camelia Manuela MîrzaPathophysiology, Department 1-Morpho-Functional Sciences, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Victor Babeş Str., No. 2-4, 400012 Cluj-Napoca, Romania.
Paul Mihai BoarescuDepartment of Medical-Surgical and Complementary Sciences, Faculty of Medicine and Biological Sciences, "Ștefan cel Mare" University of Suceava, Universității Str., No. 13, 720229 Suceava, Romania.ORCID 0000-0001-6185-7129
Sorana D BolboacăMedical Informatics and Biostatistics, Department 11-Medical Education, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, Romania.ORCID 0000-0002-2342-4311
Adriana-Elena BulboacăPathophysiology, Department 1-Morpho-Functional Sciences, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Victor Babeş Str., No. 2-4, 400012 Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimOur study aimed to evaluate serum oxidative stress-related biomarkers (three pro-oxidants: total oxidant status (TOS), indirect assessment of nitric oxide synthesis (NOx), and malondialdehyde (MDA), and three anti-oxidants: total anti-oxidant capacity (TAC), catalase (CAT), and thiols) in patients with keratoconus (KCN).

methodsWe conducted a single-center, cross-sectional study with the prospective enrollment of adult patients attending an outpatient ophthalmology clinic between 1 January 2024, and 1 September 2025. The diagnosis of KCN was established based on the clinical signs and two or more aberrant Pentacam parameters.

resultsWe evaluated 44 subjects with KCN (median age, 26 years) and 38 without KCN (median age, 28 years), with similar age and sex distributions (

conclusionsOur findings indicate a systemic imbalance between pro-oxidant and anti-oxidant biomarkers in subjects with keratoconus.

Indexed as

biomarkerkeratoconus (KCN)nitric oxideoxidative stresstotal anti-oxidant statustotal oxidant status

Identifiers

PMID41897434
PMCPMC13024571

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