Evidence map›Paper›PMID 41897422›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Nox1-Derived ROS Amplifies Calcium Entry and Enhances Pneumolysin-Induced Lung Endothelial Barrier Dysfunction in Hyperglycemia.

Stephen Haigh, Feng Chen, Yanfang Yu, Zsuzsanna Bordan, Xueyi Li, Supriya Sridhar, Maritza J Romero, Trinad Chakraborty, Gabor Csanyi, Austin T Joshua and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Stephen HaighVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Feng ChenDepartment of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0003-3508-8834
Yanfang YuDepartment of Forensic Medicine, Nanjing Medical University, Nanjing 211166, China.
Zsuzsanna BordanVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8409-3712
Xueyi LiDepartment of Genetics, Stanford University, Palo Alto, CA 94304, USA.
Supriya SridharVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Maritza J RomeroVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Trinad ChakrabortyInstitute for Medical Microbiology, Justus-Liebig University, Schubertstraße 81, 35392 Giessen, Germany.
Gabor CsanyiVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Austin T JoshuaVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Tej V PatelVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0001-9967-4755
Zachary L BrownVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1590-4534
Mitchel A ShiversVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Hunter G SellersVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-8994-9404
Farhana AnannaVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Tohru FukaiVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9864-571X
Masuko Ushio-FukaiVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Eric J Belin de ChantemeleVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-0184-3830
Alexander VerinVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
David W SteppVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Rudolf LucasVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3805-8868
David J R FultonVascular Biology Center, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1528-1517

Funding

Calpain/talin/MLCP axis in pulmonary endothelial barrier regulationR01HL158909 · NHLBI · AUGUSTA UNIVERSITY · PI SU, YUNCHAO, VERIN, ALEXANDER D · 2022 to 2025
$2.9M
Mitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and AngiogenesisR01HL160014 · NHLBI · AUGUSTA UNIVERSITY · PI USHIO-FUKAI, MASUKO · 2021 to 2024
$2.0M
HDAC9 nuclear/cytoplasmic shuttling in pulmonary vascular endothelial barrier regulationR01HL157440 · NHLBI · AUGUSTA UNIVERSITY · PI VERIN, ALEXANDER D · 2022 to 2025
$1.5M
NHLBI NIH HHS R01 HL157440NHLBI NIH HHS R01 HL158909NHLBI NIH HHS R01 HL160014
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

calciumendothelial barrierlungmPTPNOX1obesitySTIM1TRPC1

Identifiers

PMID41897422
PMCPMC13024285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.