Evidence map›Paper›PMID 41897408›Full record

ReviewBiomolecules2026

Palmitoylation in Renal Physiology and Pathology.

Jingru Ma, Zhen Zhang, Jiaqi Guo, Hu Cai, Jian Yao, Dahai Yang, Huiyuan Zhu, Haijing Liu, Changhe Wang, Hongbo Xu

Abstract readReview
In one paragraph

Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingru MaShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Zhen ZhangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Jiaqi GuoShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Hu CaiShaanxi Medical Devices Quality Testing Institute, Xixian New Area, Xianyang 712046, China.
Jian YaoDivision of Molecular Signaling, Department of the Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Japan.ORCID 0000-0003-2622-0215
Dahai YangShaanxi Center for Technical Review of Pharmaceutical Products, 56 Gaoxin 6th Road, Yanta District, Xi'an 710065, China.
Huiyuan ZhuShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Haijing LiuShaanxi Institute for Food and Drug Control, High-Tech Zone, Xi'an 710075, China.
Changhe WangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Hongbo XuShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712046, China.

Funding

Shaanxi Provincial Key Research and Development Program 2023-ZDLSF-08the "Double Chain Integration" Young and Middle-aged Scientific Research Innovation Team Project of Shaanxi Provincial Administration of Traditional Chinese Medicine No. 2022-SLRH-YQ-005the Shaanxi Qinchuangyuan "Scientists + Engineers" Team Construction Project 2023KXJ-128
6 · The paper itself

Abstract

Palmitoylation is a critical post-translational modification that involves the covalent binding of palmitic acid to cysteine residues within proteins. It is widely recognized that palmitoylation plays a significant role in regulating protein membrane localization, stability, and interactions. The kidney plays a key role in maintaining fluid homeostasis and excreting metabolic waste, and its normal function relies on the precise regulation of protein function. Emerging evidence reveals the crucial role of palmitoylation in renal physiological and pathological processes. However, the intricate pathways and molecular regulators in the kidney that are involved in palmitoylation remain insufficiently elucidated. This review summarizes the role and possible underlying physiological and pathological mechanism of palmitoylation in the kidney, including enzymes and inhibitors that regulate palmitoylation, the signaling pathways involved, target proteins involved in palmitoylation, and specific modification sites. Moreover, we focus on detection techniques and corresponding research strategies for palmitoylation. This review can also serve as a practical reference to improve the understanding of palmitoylation and the treatment of kidney-related diseases.

Indexed as

KidneyKidney DiseasesLipoylationAnimalsHumansProtein Processing, Post-TranslationalSignal Transductionkidneypalmitoylationpalmitoylation detectionpost-translational modification

Identifiers

PMID41897408
PMCPMC13024260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.