Evidence map›Paper›PMID 41897362›Full record

ArticleBiomolecules2026

Differential Plasma Expression of sTNF-R, TNF-α, PDGF-AA, IL-17A, and IL-1β Across the Colorectal Neoplasia Spectrum.

Vlad-Alexandru Ionescu, Gina Gheorghe, Claudiu Stefan Turculet, Teodor Florin Georgescu, Razvan Matei Bratu, Cristina Mambet, Valentin Enache, Mihaela Gheorghiu, Daniela Pasarica, Camelia Cristina Diaconu and 2 more

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vlad-Alexandru IonescuFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Gina GheorgheFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Claudiu Stefan TurculetFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Teodor Florin GeorgescuFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Razvan Matei BratuFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Cristina MambetFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.ORCID 0000-0001-8495-7704
Valentin EnacheDepartment of Anatomical Pathology, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania.
Mihaela GheorghiuPathophysiology and Immunology Department, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Daniela PasaricaPathophysiology and Immunology Department, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
Camelia Cristina DiaconuFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.ORCID 0000-0001-6837-260X
Carmen Cristina DiaconuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.ORCID 0000-0002-2259-1425
Coralia BleotuDepartment of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, 030304 Bucharest, Romania.ORCID 0000-0002-9031-338X

Funding

European Regional Development Fund (ERDF), Competitiveness Operational Programme (COP) A1.1.4. ID: P_37_798 MYELOAL-EDIAPROT SMIS 106774Ministry of Investments and European Projects, through the Managing Authority for the Health Program, PS/272/PS_P5/OP1/RSO1.1/PS_P5_RSO1.1_A9-ROGEN Project SMIS 324809
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the most important causes of cancer-related mortality worldwide, underscoring the need to better understand systemic inflammatory pathways across the colorectal neoplasia spectrum. In this exploratory case-control study, we characterized plasma levels of key inflammatory mediators in healthy individuals and patients with colorectal polyps or CRC. Healthy controls (

Indexed as

Colorectal NeoplasmsInterleukin-17Interleukin-1betaPlatelet-Derived Growth FactorTumor Necrosis Factor-alphaAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedIL17A protein, humanInterleukin-17Interleukin-1betaPlatelet-Derived Growth Factorplatelet-derived growth factor ATumor Necrosis Factor-alphacolorectal cancerIL-17AIL-1βPDGF-AAsTNF-RTNF-α

Identifiers

PMID41897362
PMCPMC13023994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.