Evidence map›Paper›PMID 41897325›Full record

ReviewBiomolecules2026

The Emerging Roles of Protein Lipidation in Fertility and Reproductive Disorders: Mechanisms and Therapeutic Implications.

Heran Cao, Xiaohua Liu, Shenghui Zhu, Hua Nie, Shujuan Liu, Jun Fan, Weibing Qin

Abstract readReview
In one paragraph

Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heran CaoDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou 510632, China.
Xiaohua LiuThe NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute, Guangzhou 510632, China.
Shenghui ZhuThe NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute, Guangzhou 510632, China.
Hua NieThe NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute, Guangzhou 510632, China.
Shujuan LiuCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Jun FanDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou 510632, China.ORCID 0000-0001-6637-9891
Weibing QinThe NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute, Guangzhou 510632, China.

Funding

the Medical Research Foundation of Guangdong Province A2023049the Natural Science Foundation of Guangdong Province 2023A1515010504
6 · The paper itself

Abstract

Protein lipidation, a pivotal post-translational modification, dynamically regulates cellular signaling, membrane trafficking, and protein stability, with emerging roles in reproductive physiology. However, the systematic understanding of how distinct lipid modifications orchestrate physiological processes in male and female reproduction remains incomplete. This review systematically elaborates the mechanistic contributions of protein lipidation to gametogenesis, fertilization, and reproductive homeostasis. Finally, we discuss emerging therapeutic strategies targeting lipidation pathways-including inhibitors of palmitoylation (2-BP) and prenylation (lonafarnib)-and highlight their potential for treating infertility and reproductive disorders.

Indexed as

FertilityInfertilityProtein Processing, Post-TranslationalProteinsAnimalsFemaleHumansLipoylationMaleProtein PrenylationProteinsfemale reproductioninfertilitymale reproductionpost-translational modificationsprotein lipidationtherapeutic targets

Identifiers

PMID41897325
PMCPMC13024116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.