ArticleChildren (Basel, Switzerland)2026
Perceived Social Support and Depressive Symptoms in AYA Cancer Patients: A Mediation Analysis of Hope Agency and Pathways.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesAdolescent/young adult (AYA) cancer patients experience a variety of challenges, including higher rates of depressive symptoms (D) than healthy controls. Although various forms of social support (SS) seem to be a protective factor against D, AYAs also experience significant disruptions to SS. Snyder's hope theory involves two interrelated components: agency (the belief in one's ability to initiate or sustain action toward a desired goal) and pathways (the belief in one's ability to produce workable routes to desired goals). Because hope, particularly the agency component, has been linked to both SS and D, it may mediate the relationship between the two.
methodsAn online questionnaire was completed by AYA cancer patients (
resultsAgency mediated the relationship between PSS and D in AYA women with cancer, but not men. Pathways did not mediate the relationship between PSS and D.
conclusionsGiven the significantly higher prevalence of depression in women with cancer as compared to men, interventions to enhance agency are an important adjunct to methods to promote PSS in AYA women with cancer.
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