Evidence map›Paper›PMID 41897122›Full record

ArticleChildren (Basel, Switzerland)2026

ABR Features in Ski-Slope Hearing Loss for Hearing Threshold Estimation: A Comparative Clinical Study of Click and CE-Chirp Stimuli.

Davide Brotto, Giuseppe Impalà, Elisa Lovato, Elena Mazzaro, Marco Maculan, Elisabetta Zanoletti, Nicole Galoforo, Patrizia Trevisi

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Davide BrottoSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.ORCID 0000-0002-6291-4399
Giuseppe ImpalàUnit of Otolaryngology, Azienda Ospedale Università Padova, via Giustiniani 2, 35128 Padua, Italy.ORCID 0009-0009-6742-096X
Elisa LovatoSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.
Elena MazzaroSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.
Marco MaculanSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.
Elisabetta ZanolettiSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.
Nicole GaloforoSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.
Patrizia TrevisiSection of Otolaryngology, Department of Neurosciences DNS, University of Padova, via Belzoni 160, 35121 Padua, Italy.ORCID 0000-0002-5037-8568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAuditory brainstem responses (ABRs) are widely used for objective hearing threshold estimation in both adults and children. Click and CE-Chirp stimuli differ substantially in cochlear activation and neural synchrony, yet their relative performance in patients with ski-sloping hearing loss remains insufficiently characterized, particularly with regard to pediatric diagnostic implications.

methodsThis study compared ABRs elicited by click and CE-Chirp stimuli in adults with ski-sloping sensorineural hearing loss. The same comparison was also performed in a pediatric cohort including hearing-impaired and normal-hearing children. Adult subjects were further stratified according to audiometric configuration (DROP 1 kHz vs. DROP 2 kHz). ABR thresholds, wave V latency, amplitude, and detectability were analyzed across stimulus types and intensity levels. Associations between ABR thresholds and behavioral audiometric measures were also examined.

resultsIn adults with ski-sloping hearing loss, CE-Chirp stimulation yielded significantly lower ABR threshold estimates than click stimulation, particularly in the DROP 2 kHz subgroup, and showed stronger correlations with behavioral pure-tone averages across low-, mid-, and high-frequency ranges. Wave V latencies were consistently shorter with CE-Chirp stimulation, while wave V amplitudes did not differ significantly between stimuli at suprathreshold levels. In children, ABR thresholds obtained with CE-Chirp were generally equal to or lower than those obtained with clicks, although statistical significance was limited by sample size. CE-Chirp stimulation was associated with shorter wave V latencies in both hearing-impaired and normal-hearing children and produced larger wave V amplitudes at selected suprathreshold intensities in hearing-impaired children.

conclusionsClick and CE-Chirp stimuli provide complementary information in ABR assessment. While click stimulation remains essential for robust waveform identification, CE-Chirp stimulation appears to offer advantages in threshold estimation and neural synchrony, particularly in ski-sloping hearing loss and pediatric evaluations. Discrepancies between click- and CE-Chirp-derived ABR thresholds should not be attributed solely to maturational or synchrony-related factors but may warrant further frequency-specific audiological assessment to optimize diagnosis and rehabilitation strategies.

Indexed as

auditory brainstem responseCE-Chirpclickhigh-frequency hearing losspediatric audiologyski-slope hearing loss

Identifiers

PMID41897122
PMCPMC13025049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.