ArticleChildren (Basel, Switzerland)2026
Early Postoperative Analgesic Outcomes Following Pre-Induction Intravenous Ibuprofen in Children Undergoing Hypospadias Repair: A Randomized Controlled Study.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundHypospadias repair is a pediatric surgical procedure associated with relatively pronounced postoperative pain. However, evidence guiding procedure-specific perioperative analgesic strategies remains limited. Although preoperative intravenous ibuprofen has demonstrated analgesic benefits in other pediatric surgical settings, data specific to pediatric urological surgery are scarce.
methodsIn this randomized, double-blind, placebo-controlled trial, 104 children (2-7 years old, American Society of Anesthesiologists [ASA] physical status I-II) scheduled for urethroplasty were randomized to receive either intravenous ibuprofen (10 mg/kg; Group I) or saline (Group C) before anesthesia induction. The primary outcome was the proportion of patients requiring rescue opioid analgesia in the postanesthesia care unit (PACU). Secondary outcomes included postoperative FLACC (Face, Legs, Activity, Cry, Consolability), NRS-11 (the numerical rating scale-11 scale), and PAED (Pediatric Anesthesia Emergence Delirium) scores, repeated rescue analgesia, intraoperative opioid use, the LMA (laryngeal mask airway) removal time, and adverse events.
resultsNinety-three patients completed the study (Group I,
conclusionsPre-induction intravenous ibuprofen reduced early postoperative rescue analgesia requirements without increasing adverse events in children undergoing hypospadias repair.
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