Evidence map›Paper›PMID 41896991›Full record

ArticleBiology of sex differences2026

Sex differences in congenital hereditary endothelial dystrophy (CHED) and Slc4a11

Wenlin Zhang, Divya Sree Ramya, Eduardo Araujo, Jhuwala Venkatakrishnan, Saloni Gupta, Isa Matsubayashi, Marco Morselli, Ananya Kaginalkar, Sunita Chaurasia, Matteo Pellegrini and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wenlin ZhangStein Eye Institute, David Geffen School of Medicine at UCLA, UCLA, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095-7003, USA. wenlinzhang@mednet.ucla.edu.
Divya Sree RamyaJasti V Ramanamma Children's Eye Care Center, The Cornea Institute, & Institute for Rare Eye Diseases and Ocular Genetics L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
Eduardo AraujoStein Eye Institute, David Geffen School of Medicine at UCLA, UCLA, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095-7003, USA.
Jhuwala VenkatakrishnanStein Eye Institute, David Geffen School of Medicine at UCLA, UCLA, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095-7003, USA.
Saloni GuptaStein Eye Institute, David Geffen School of Medicine at UCLA, UCLA, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095-7003, USA.
Isa MatsubayashiStein Eye Institute, David Geffen School of Medicine at UCLA, UCLA, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095-7003, USA.
Marco MorselliDepartment of Molecular, Cell & Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Ananya KaginalkarDr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Sunita ChaurasiaJasti V Ramanamma Children's Eye Care Center, The Cornea Institute, & Institute for Rare Eye Diseases and Ocular Genetics L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
Matteo PellegriniDepartment of Molecular, Cell & Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Radhika TandonDr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Muralidhar RamappaJasti V Ramanamma Children's Eye Care Center, The Cornea Institute, & Institute for Rare Eye Diseases and Ocular Genetics L.V. Prasad Eye Institute, Hyderabad, Telangana, India.
Arthur ArnoldDepartment of Integrative Biology & Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Anthony J AldaveStein Eye Institute, David Geffen School of Medicine at UCLA, UCLA, University of California Los Angeles, 200 Stein Plaza, Los Angeles, CA, 90095-7003, USA. aldave@jsei.ucla.edu.

Funding

NEI core grant P30EY000331Research to Prevent Blindness Unrestricted Grant
6 · The paper itself

Abstract

backgroundSex differences have been described in several corneal diseases such as Fuchs endothelial corneal dystrophy and keratoconus, with estrogens implicated in the induction of these differences. Here, we report the identification of sex differences in a cohort of 177 individuals with Corneal Hereditary Endothelial Dystrophy (CHED), a rare corneal endothelial dystrophy associated with biallelic SLC4A11 gene mutations, and in a Slc4a11

methodsCentral corneal thickness (CCT) was measured in individuals with CHED and in Slc4a11

resultsMale sex is associated with increased CCT, and thus more severe corneal edema, the characteristic clinical feature of CHED, in affected individuals and Slc4a11

conclusionsMale sex is associated with a more severe corneal phenotype in individuals with CHED and a Slc4a11

Indexed as

Corneal Dystrophies, HereditarySex CharacteristicsSLC4A ProteinsAnimalsAnion Transport ProteinsAntiportersDisease Models, AnimalFemaleHumansMaleMiceMice, KnockoutSymportersAnion Transport ProteinsAntiportersSLC4A11 protein, humanSlc4a11 protein, mouseSLC4A ProteinsSymportersCHED (Congenital Hereditary Endothelial Dystrophy)Corneal edemaEstrogenGene therapyLipid β-oxidationOxidative stressSex differencesSlc4a11 -/- mouse modelSolute carrier family 4 member 11 gene (SLC4A11)Transcriptomic analysis

Identifiers

PMID41896991
PMCPMC13151172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.