ArticleStem cell research & therapy2026
Proliferation-dependent adipogenic differentiation of progenitor cells in rat coronary artery explants.
Article in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipid accumulation is involved in pathogenesis of cardiovascular disease. Progenitor cells are associated with the disease progression; however, their identity remains unclear. We therefore set out to investigate whether adipogenic differentiation occurs in rat coronary artery explants, identify progenitor cells involved, and determine the role of proliferation in this process.
methodsRat coronary artery explants were cultured ex vivo in adipogenic differentiation medium for 14 days. Lipid accumulation and adipocyte marker secretion were assessed using Oil Red O staining, LipidSpot immunofluorescence, and ELISA for FABP4 and adiponectin. Progenitor cell identity and proliferation were characterized by immunofluorescence for Gli1, Ki67, vimentin, and BrdU incorporation at specific intervals. Pharmacological inhibition of proliferation occurred using BrdU and confirmed with the MEK1/2 inhibitor trametinib. Transcriptomic profiling compared adipocyte-enriched and progenitor-enriched populations.
resultsCoronary artery segments cultured under adipogenic conditions accumulated lipids and secreted FABP4 and adiponectin over time. Gli1
conclusionsThis study provides the first evidence in rat coronary artery explants of proliferation-dependent adipogenic differentiation from Gli1
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.