Evidence map›Paper›PMID 41896865›Full record

ArticleJournal of nanobiotechnology2026

Self-actuated probiotic-nanozyme hybrid system with mucus penetration, biofilm eradication and microbiota regulation for Helicobacter pylori infection.

Wei Zhang, Yanan Zhou, Zijun Li, Zhaowen Wang, Fangzheng Zhu, Yaoyu Zou, Nianshuang Li, Cong He, Nonghua Lu, Xiaolei Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei ZhangDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Yanan ZhouDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Zijun LiThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Zhaowen WangThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Fangzheng ZhuThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Yaoyu ZouDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Nianshuang LiDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Cong HeDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Nonghua LuDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China.
Xiaolei WangThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China. wangxiaolei@ncu.edu.cn.
Yin ZhuDepartment of Gastroenterology, Institute of Digestive Disease, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, P.R. China. ndyfy01977@ncu.edu.cn.

Funding

Interdiscipline Innovation Foundation of Nanchang University PYJX20230001Jiangxi Clinical Research Center for Gastroenterology 20223BCG74011Key Laboratory of Bioengineering Drugs in Jiangxi Province 2024SSY07061Key Laboratory Project of Digestive Diseases in Jiangxi Province 2024SSY06101National Natural Science Foundation of China 32560229National Natural Science Foundation of China 82170580National Natural Science Foundation of China 82400780Natural Science Foundation of Jiangxi Province 20242BAB20432Natural Science Foundation of Jiangxi Province 20242BAB26117Noncommunicable Chronic Diseases-National Science and Technology Major Project of China 2025ZD0545302Postdoctoral Fellowship Program of CPSF GZB20230283
6 · The paper itself

Abstract

Helicobacter pylori (H. pylori) infection has emerged as a serious risk factor for global human health. Current antibiotic-based clinical eradication therapies still have many challenges, including inadequate drug permeability across the gastric mucus barrier, H. pylori biofilm-induced antibiotic resistance and recurrent infections, as well as gut dysbacteriosis. Herein, we report a probiotic-nanozyme hybrid system (LP@FeTA/CuPt), which is formed by coupling polyphenol-coated Lactobacillus plantarum (LP@FeTA) and CuPt nanozymes. LP@FeTA effectively penetrates the gastric mucus barrier via autokinetic movement, and facilitates the targeted delivery of CuPt nanozymes within H. pylori biofilms by "eating" extracellular polymeric substances (EPS). CuPt nanozymes respond to the acidic and H

Indexed as

Anti-Bacterial AgentsBiofilmsHelicobacter InfectionsHelicobacter pyloriMucusProbioticsAnimalsCopperHumansLactiplantibacillus plantarumMicrobiotaReactive Oxygen SpeciesAnti-Bacterial AgentsCopperReactive Oxygen SpeciesAntibacterialCuPt nanozymeEngineered probioticH. pylori infection

Identifiers

PMID41896865
PMCPMC13151254

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.