Trial reportBMC oral health2026
Comparing two types of platelet-rich fibrin membranes in the management of dehiscence defects with simultaneous implant placement in the posterior mandible: a randomized controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07164417 (Comparing Two Types of PRF Membranes in Management of Dehiscence Defect With Simultaneous Implant Placement in Posterior Mandible), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Two Types of PRF Membranes in Management of Dehiscence Defect With Simultaneous Implant Placement in Posterior Mandible (Randomized Controlled Clinical Trial)
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlveolar ridge resorption after tooth extraction may compromise implant placement and frequently necessitates guided bone regeneration (GBR). Platelet-rich fibrin (PRF) is widely used in oral surgery; extended PRF (e-PRF) has been proposed to prolong growth factor availability and membrane stability. This randomized clinical trial compared PRF and e-PRF membranes combined with bovine xenograft for horizontal ridge augmentation with simultaneous implant placement in the posterior mandible.
methodsTwenty patients with posterior mandibular ridge deficiencies (residual ridge width 4–6 mm) were randomized (1:1) to receive xenograft + PRF (control, n = 10) or xenograft + e-PRF (study, n = 10) at the time of implant placement. Primary outcome: horizontal bone width gains at 6 months assessed by standardized CBCT measurements 1 mm apical to implant platform. Secondary outcomes: implant stability quotient (ISQ) at baseline and 6 months, postoperative pain (VAS), and edema. Sample size was calculated to detect the expected difference in ISQ change with 80% power and α = 0.05. Statistical tests included paired and independent t-tests, repeated measures analyses, and non-parametric tests where appropriate. Significance threshold was p ≤ 0.05.
resultsTwenty patients (30 implants; 8 males, 12 females; mean age 40.2 ± 5.3 years) completed the study. Baseline characteristics and residual ridge widths were similar between groups. Implant stability (ISQ) increased significantly within both groups from baseline to 6 months (p < 0.001) but did not differ between groups at either time point (baseline p = 0.622; 6 months p = 0.263). Postoperative pain and edema followed similar, transient patterns in both groups (no significant between-group differences). At 6 months, horizontal bone gain was significantly greater in the e-PRF group (mean gain 2.28 ± 0.79 mm) than in the PRF group (0.75 ± 0.18 mm), p < 0.001.
conclusionsIn this randomized clinical trial, both PRF and e-PRF combined with bovine xenograft and simultaneous implant placement produced favorable clinical outcomes, while e-PRF provided superior horizontal bone gain at 6 months. Further larger and longer-term trials with prospective registration are recommended to confirm these findings.
trial registrationThe study protocol approved by the Institutional Review Board of the Faculty of Dentistry, Alexandria University, Egypt (IRB No. 0936-06/2024–00010556). This trial was retrospectively registered at ClinicalTrials.gov (ID: NCT07164417, Date of registration: 04/09/2025; https://clinicaltrials.gov/study/NCT07164417 ). All participants provided written informed consent before enrollment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.