SynthesisBMC endocrine disorders2026
Endocrine and neurological complications in total versus completion thyroidectomy: a systematic review and meta-analysis.
Synthesis in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal extent of thyroidectomy remains controversial. Total thyroidectomy (TT) offers definitive disease control but it may raise the complications and completion thyroidectomy (CT) following initial lobectomy might lower the morbidity. This meta-analysis and systematic review compared TT and CT using endocrine and neurological outcomes in the postoperative period.
methodsWe searched databases of PubMed, Scopus, Embase, Web of Science and Google Scholar in accordance with PRISMA and until September 1, 2025. Articles that reported postoperative endocrine and neurological complications of both TT and CT were selected. Quality evaluation was assessed by Joanna Briggs Institute (JBI). The random-effects model in STATA 17 was used to compute pooled odds ratios (ORs), and heterogeneity was assessed using I 2 and Cochran Q. Sensitivity analyses were done to determine the strength of findings.
resultsForty-nine articles were incorporated. TT was related to increased odds of overall hypocalcemia (OR = 1.74; 95% CI: 1.302.34), transient hypocalcemia (OR = 1.67; 95% CI: 1.09 2.55), and transient hypoparathyroidism (OR = 1.53; 95% CI: 1.002.33) in comparison with CT, whereas permanent hypocalcemia was increased moderately (OR = 1.27; 95% CI: 1.16–1.40). Neurological, such as recurrent laryngeal nerve (RLN) palsy (OR = 0.90; 95% CI: 0.671.21) and the RLN injury (OR = 0.45; 95% CI: 0.151.05) showed no significant results between the two procedures. These results were validated by sensitivity analyses on the consistency of the results across the study quality strata.
conclusionTT is linked to higher occurrence of transient endocrine complications but is equal to CT regarding neurological safety. These findings emphasize the role of personalized surgical decision-making, careful parathyroid conservation, and standardized perioperative care as ways of reducing the risk of complications and maximizing the outcome of thyroid surgery. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.