Trial reportBMC cardiovascular disorders2026
Evaluation of safety and affection of variable duration of dual antiplatelet therapy using aspirin plus ticagrelor after successful percutaneous coronary intervention for diabetic patients with acute coronary syndrome.
Trial report in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundAtherosclerotic cardiovascular disease (ASCVD) represents the primary cause of morbidity and mortality among cases with diabetes. PURPOSE: To determine whether a strategy of ticagrelor monotherapy initiated after 3 months of dual antiplatelet treatment (DAPT) modifies the rate of major adverse cardiovascular effect (MACE) as the primary endpoint and bleeding events as the secondary endpoint, relative to a 12-month regimen of ticagrelor-based DAPT in diabetic cases with acute coronary syndrome (ACS) treated by Percutaneous coronary intervention (PCI).
methodsThis randomized, open-label study included 400 diabetic patients with acute coronary syndrome (STEMI or NSTEMI) treated with PCI. Patients were randomly assigned to receive ticagrelor monotherapy after 3 months of DAPT or to continue ticagrelor plus aspirin for 12 months. The primary endpoint was major adverse cardiovascular events (MACE), and the secondary endpoint was bleeding events.
resultsHemoglobin level after three month was substantially higher in group 1, the mean ± SD was 12.97 ± 1.7 g/dl while group 2 was 12.6 ± 1.47 g/dl (p = 0.02). Platelet count did not differ markedly between groups. Similarly, the incidence of complications—mortality, chest pain, bleeding, ICH, ischemic stroke, recurrent MI, and repeated PCI—showed no significant variation between them. There was no significant difference in the incidence of MACE between the two groups during 12 months of follow-up. Ticagrelor monotherapy was associated with a lower incidence of overall bleeding events, mainly driven by reductions in mild bleeding, while rates of moderate or severe bleeding were comparable between groups.
conclusionsSwitching to ticagrelor monotherapy after 3 months of DAPT results in a significant reduction in bleeding events among diabetic cases with ACS undergoing PCI, while maintaining a comparable safety profile regarding complications.
trial registrationPan African Clinical Trials Registry (PACTR202511832264697) Date of registration 24 November 2025.
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