Evidence map›Paper›PMID 41896627›Full record

ArticleScientific reports2026

Fungal-mediated green synthesis of ZnO-MnO nanocomposites with antimicrobial and anticancer properties.

Samy Selim, Ahmad Alhujaily, Ebrahim Saied, Amr H Hashem, Fathy M Elkady, Amer M Abdelaziz, Mohammed S Abdulrahman, Faisal Alsenani, Hiba Shaghaleh, Hattan S Gattan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samy SelimDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 72388, Saudi Arabia. sabdulsalam@ju.edu.sa.
Ahmad AlhujailyDepartment of Biology, College of Science, Taibah University, Madinah, 42353, Saudi Arabia.
Ebrahim SaiedBotany and Microbiology Department, Faculty of Science, Al-Azhar University, P.O. Box 11884, Cairo, Egypt.
Amr H HashemBotany and Microbiology Department, Faculty of Science, Al-Azhar University, P.O. Box 11884, Cairo, Egypt.
Fathy M ElkadyMicrobiology and Immunology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Amer M AbdelazizBotany and Microbiology Department, Faculty of Science, Al-Azhar University, P.O. Box 11884, Cairo, Egypt.
Mohammed S AbdulrahmanMicrobiology and Immunology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Faisal AlsenaniDepartment of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura University, Makkah, 24381, Saudi Arabia.
Hiba ShaghalehSchool of Energy and Environment, Southeast University, Nanjing, 210096, China.
Hattan S GattanDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohammed H AlruhailiSpecial Infectious Agents Unit, King Fahad Medical Research center, King AbdulAziz University, Jeddah, Saudi Arabia.
Mohanned T AlharbiDepartment of Basic Medical Sciences, Collage of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Ahmed M HusseinDepartment of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Vienna, Austria. ahmed.hussein@univie.ac.at.

Funding

This work was funded by the Deanship of Graduate Studies and Scientific Research at Jouf University DGSSR-2025-FC-01007
6 · The paper itself

Abstract

The urgent need for sustainable therapeutic nanomaterials has driven interest in green synthesis routes. In this study, zinc oxide-manganese oxide nanocomposites were mycosynthesized by employing the fungal extracellular filtrate of Aspergillus terreus. Characterization based on different spectroscopical analysis confirmed their crystalline structure, associated functional groups, and nanoscale morphology. The obtained composites showed nanoscales with average particle sizes of 75 nm and 99 nm as determined by TEM and DLS analysis, respectively. Additionally, microbiological assays revealed their strong growth-ceasing activity against Escherichia coli and Bacillus subtilis strains. Also, the time-kill assessment demonstrated rapid bacterial reduction at higher nanocomposite doses. Cytotoxicity studies indicated good safety in the case of WI-38 normal cells, potent anticancer activity against the MCF-7 tumor cell line, and a respectable selectivity index approximately 3.4 for the tested cancerous cell line. These findings highlight fungal-mediated biosynthesis as an eco-friendly route for producing zinc oxide-manganese oxide nanocomposites with respected spectrum antimicrobial activity and anticancer potential.

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAspergillusManganese CompoundsNanocompositesOxidesZinc OxideBacillus subtilisEscherichia coliGreen Chemistry TechnologyHumansMCF-7 CellsMicrobial Sensitivity TestsAnti-Infective AgentsAntineoplastic AgentsManganese Compoundsmanganese oxideOxidesZinc OxideAntibacterial activityAnticancer potentialAspergillus terreusEco-friendly synthesisMycosynthesisZnO-MnO nanocomposites

Identifiers

PMID41896627
PMCPMC13039167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.