Evidence map›Paper›PMID 41896624›Full record

ArticleScientific reports2026

Zinc finger protein Y - linked as a potential biomarker for autoimmune hepatitis and multiple sclerosis which overlap with immune infiltration.

Jian Liu, Di Guo, Meng Pu, Xin Li, Ying Xiao, Zi-Wei Zhang, Yi-Bin Tang, Yang Liu, Cun-Gen Ma, Qing Wang

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jian Liu *Research Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China.
Di Guo *College of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong, 030619, PR China.
Meng PuResearch Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China.
Xin LiCollege of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong, 030619, PR China.
Ying XiaoCaidian District People's Hospital, Wuhan, 430100, Hubei, China.
Zi-Wei ZhangResearch Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China.
Yi-Bin TangResearch Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China.
Yang LiuCollege of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong, 030619, PR China. liuyang1980@sxtcm.edu.cn.
Cun-Gen MaResearch Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China. macungen@sxtcm.edu.cn.
Qing WangResearch Center of Neurobiology, The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, Shanxi, China. 4024771456@163.com.

Funding

Basic Research Project of Shanxi Province No. 202303021221162Discipline Construction Fund of Shanxi University of Chinese Medicine No. 2024XKJS-02Shanxi University of Chinese Medicine 2022 Science and Technology Innovation Team No. 2022TD2006Traditional Chinese Medicine Innovation Team of Shanxi Provincial Administration of Traditional Chinese Medicine No. zyytd2024039
6 · The paper itself

Abstract

Autoimmune Hepatitis (AIH) and Multiple Sclerosis (MS) are chronic inflammatory diseases with abnormal immune responses. This study aims to identify common biomarkers for AIH and MS using bioinformatics analysis. Gene expression data of AIH (GSE159676) and MS (GSE131279 and GSE131281) were obtained from the GEO database. Differentially Expressed Genes (DEGs) were identified using the limma package in R. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Protein-Protein Interaction (PPI) network, and machine learning algorithm Least Absolute Shrinkage and Selection Operator (LASSO) regression were used to evaluate potential biomarkers. The common biomarker gene Zinc Finger Protein Y-linked (ZFY) was identified. KEGG analysis showed significant enrichment of the Phosphatidylinositol 3-Kinase/Protein Kinase B (PI3K/Akt) pathway in both diseases. LASSO regression identified ZFY as a potential diagnostic marker, with decreased expression in both AIH and MS groups. Single-gene immune infiltration analysis indicated a significant association between ZFY expression and immune cell infiltration levels. Experimental validation in ConA-induced hepatitis and CPZ-mediated demyelination model mice further verified the diagnostic potential of ZFY. This study reveals the potential of ZFY as a biomarker for AIH and MS, highlighting its role in the PI3K/Akt pathway and immune infiltration. These findings provide new insights into the common pathological mechanisms of AIH and MS and suggest potential targets for future therapeutic strategies.

Indexed as

Hepatitis, AutoimmuneMultiple SclerosisAnimalsBiomarkersComputational BiologyGene Expression ProfilingHumansMicePhosphatidylinositol 3-KinasesProtein Interaction MapsSignal TransductionBiomarkersPhosphatidylinositol 3-KinasesAutoimmune hepatitisBioinformatics analysisImmune infiltration analysisMultiple sclerosisPI3K/Akt pathwayZFY gene

Identifiers

PMID41896624
PMCPMC13039438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.