Evidence map›Paper›PMID 41896597›Full record

ArticleScientific reports2026

Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.

Gianmauro Palombelli, Valentina Zecca, Marta Boffa, Carola Cerri, Taljinder Singh, Luisa De Risio, Mauro Pettorruso, Francesca Zoratto, Rossella Canese

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Gianmauro PalombelliMRI Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy.
Valentina ZeccaMRI Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy.
Marta BoffaCentre for Behavioural Sciences and Mental Health, Istituto Superiore Di Sanità, Rome, Italy.
Carola CerriCentre for Behavioural Sciences and Mental Health, Istituto Superiore Di Sanità, Rome, Italy.
Taljinder SinghMRI Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy.
Luisa De RisioDepartment of Mental Health and Addiction, ASL Roma 5, Colleferro, Rome, Italy.
Mauro PettorrusoDepartment of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Francesca ZorattoCentre for Behavioural Sciences and Mental Health, Istituto Superiore Di Sanità, Rome, Italy. francesca.zoratto@iss.it.
Rossella CaneseMRI Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy.

Funding

European Union-NextGenerationEU-PNRR M6C2 PNRR-MCNT2-2023-12377068Italian Ministry of Health GR-2019-12370173
6 · The paper itself

Abstract

Major depressive disorder is highly prevalent and disabling, and many patients do not respond to standard therapies, resulting in treatment-resistant depression (TRD). Progress in TRD requires preclinical models with poor response to conventional treatments. The Wistar-Kyoto rat exposed to chronic mild stress (WKY/CMS) offers a robust paradigm: it shows limited responsiveness to standard antidepressants yet remains sensitive to interventions effective in TRD (esketamine, ECT), making it well-suited to probe TRD mechanisms and evaluate candidate therapies. To extend the characterization of this model-previously unstudied with quantitative

Indexed as

BrainDepressive Disorder, Treatment-ResistantNeuroimagingStress, PsychologicalAnimalsDiffusion Tensor ImagingDisease Models, AnimalHippocampusMaleRatsRats, Inbred WKY

Identifiers

PMID41896597
PMCPMC13039346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.