Evidence map›Paper›PMID 41896551›Full record

ArticleNature communications2026

TaCNGC-2A suppresses seed dormancy and activates pre-harvest sprouting through modulating calcium and hormonal signaling pathways.

Bingbing Tian, Yuhui Fang, Yingjun Zhang, Xinran Cheng, Jiajia Cao, Cheng Kou, Wei Liu, Zhaoyu Yu, Jing Chen, Buyun Li and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unlocking the genetic potential ofFrontiers in plant science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Bingbing Tian *Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Yuhui Fang *Institute of Crop Molecular Breeding, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Yingjun Zhang *Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences, Laboratory of Crop Genetics and Breeding of Hebei, Shijiazhuang, China.
Xinran Cheng *Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Jiajia Cao *Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Cheng KouInstitute of Crop Molecular Breeding, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Wei LiuKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Zhaoyu YuKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Jing ChenKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Buyun LiKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Huanfeng WangKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Shuying LeiKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Wei GaoKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Litian ZhangKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Yuxia LvKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Shengxing WangKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Hongqi SiKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Jie LuKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Can ChenKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Wenyang GeKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China.
Cheng ChangKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China. changtgw@126.com.ORCID http://orcid.org/0000-0003-2942-5216
Chuanxi MaKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China. machuanxi@139.com.ORCID http://orcid.org/0009-0009-9783-8670
Yong-Ling RuanInnovation Cluster of Crop Molecular Biology and Breeding, College of Agronomy, Anhui Agricultural University, Hefei, China. yong-ling.ruan@nwafu.edu.cn.ORCID http://orcid.org/0000-0002-8394-4474
Haiping ZhangKey Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow and Huai River Valley, College of Agronomy, Anhui Agricultural University, Hefei, China. zhanghaiping@ahau.edu.cn.ORCID http://orcid.org/0009-0006-9201-278X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31871608National Natural Science Foundation of China (National Science Foundation of China) 32372069National Natural Science Foundation of China (National Science Foundation of China) F2010123002National Natural Science Foundation of China (National Science Foundation of China) U20A2033
6 · The paper itself

Abstract

Weak seed dormancy (SD) is prone to pre-harvest sprouting (PHS), which reduces cereal yield and quality. Here, through map-based analysis, we identify TaCNGC-2A, encoding a cyclic nucleotide-gated channel protein, as a negative regulator of wheat SD. Knocking out of TaCNGC-2A enhances SD and PHS resistance, with no yield penalty. Two transcription factors, TaMYB-5B and TaMYB-5D, directly bind to the T/A mutation site of TaCNGC-2A promoter to synergistically repress its expression. The calmodulin TaCaM-3A interacts with TaCNGC-2A to jointly modulate SD and PHS resistance through influencing calcium and multiple hormonal signaling pathways. Knocking out of TaCaM-3A not only enhances SD and PHS resistance, but also increases grain weight and per-plant yield. Finally, we identify allele combinations of TaCNGC-2A and other known dormancy genes associated with strong SD. This study uncovers a regulatory mechanism underlying SD and PHS resistance and provides gene targets for breeding wheat varieties with PHS resistance.

Indexed as

CalciumCyclic Nucleotide-Gated Cation ChannelsGerminationPlant DormancyPlant Growth RegulatorsPlant ProteinsSeedsTriticumGene Expression Regulation, PlantPromoter Regions, GeneticSignal TransductionTranscription FactorsCalciumCyclic Nucleotide-Gated Cation ChannelsPlant Growth RegulatorsPlant ProteinsTranscription Factors

Identifiers

PMID41896551
PMCPMC13187048

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.