Evidence map›Paper›PMID 41896526›Full record

ArticleCell death & disease2026

ZNRF1 deficiency disrupts Fas ligand trafficking and immune balance.

Ting-Yu Lai, Yung-Chi Chang, You-Sheng Lin, Ching-Yi Tsai, Pu Ou-Yang, Chien-Chia Chen, Meng-Kun Tsai, Li-Chung Hsu, Chih-Yuan Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ting-Yu LaiDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Yung-Chi ChangInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0002-8829-5338
You-Sheng LinInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Ching-Yi TsaiDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Pu Ou-YangDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Chien-Chia ChenDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0002-1282-976X
Meng-Kun TsaiDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Li-Chung HsuInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0001-7206-5231
Chih-Yuan LeeDepartment of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC. gs2119@gmail.com.ORCID http://orcid.org/0000-0001-5034-3544

Funding

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 111-2314-B-002-266Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 112-2314-B-002-141Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 112-2326-B-002-005Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 113-2326-B-002-013
6 · The paper itself

Abstract

Fas ligand (FasL)-mediated apoptosis constrains immune responses by eliminating activated lymphocytes, yet how FasL is delivered to the plasma membrane in myeloid cells remains unclear. We identify the RING E3 ligase ZNRF1 as a macrophage-intrinsic checkpoint that licenses terminal trafficking and surface exposure of FasL. Myeloid-specific Znrf1 deletion caused age-dependent spontaneous splenomegaly and, upon allosensitization, elevated CD4

Indexed as

Fas Ligand ProteinUbiquitin-Protein LigasesAnimalsHumansMacrophagesMiceProtein TransportFas Ligand ProteinUbiquitin-Protein Ligases

Identifiers

PMID41896526
PMCPMC13149863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.